Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

14-646M TCPTP Protein, 250 µg

Un-tagged, recombinant, human TCPTP, amino acids 1-341. For use in Phosphatase Assays.

14-646M
250 µg  Also available in 10 μg size (cat#14-646) and in bulk (cat#14-646-K).
Purchase on Sigma-Aldrich

Overview

Replacement Information
Description
Catalogue Number14-646M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionTCPTP Protein, 250 µg
OverviewUn-tagged, recombinant, human TCPTP, amino acids 1-341.
References
Product Information
Quality LevelMQ300
Applications
ApplicationUn-tagged, recombinant, human TCPTP, amino acids 1-341. For use in Phosphatase Assays.
Key Applications
  • Phosphatase Assay
Biological Information
SourceHuman TCPTP, expressed in E. coli cells.
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.
Gene Symbol
  • PTPN2
  • TCELLPTP
  • TCPTP
  • TC-PTP
  • PTPT
Protein TargetTCPTP
Purification MethodGlutathione agarose affinity chromatography
Target Sub-FamilyTyr phosphatase
UniProt Number
UniProt SummarySIZE: 415 amino acids; 48528 Da
SUBUNIT: Interacts with FAM82C/PTPIP51.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: PTPA isoform is probably the major PTP expressed in human tissues. PTPB isoform was found in T-cells and in placenta.
SIMILARITY: SwissProt: P17706 ## Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. & Contains 1 tyrosine-protein phosphatase domain.
Molecular Weight39.7kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceRoutinely evaluated by dephosphorylation of DiFMUP.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size250 µg
Material PackageAlso available in 10 μg size (cat#14-646) and in bulk (cat#14-646-K).
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
14-646M 04053252924545

Documentation

Related Products & Applications

Alternative Packsize

Catalogue Number Description
14-646 TCPTP Protein, 10 µg

Product Families

Kinase & Phosphatase Products

Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
Learn More >>

Categories

Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Phosphatases
Life Science Research > Proteins and Enzymes > Purified Phosphatases