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23-058M Smurf1, active

Smurf1, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
23-058M
250 µg  
Purchase on Sigma-Aldrich

Overview

Description
Catalogue Number23-058M
Brand Family Upstate
Trade Name
  • Upstate
DescriptionSmurf1, active
Alternate Names
  • SMAD ubiquitination regulatory factor 1
  • SMAD-specific E3 ubiquitin-protein ligase 1
Background InformationSmurf1 is a member of the Nedd4-like family of E3 ligases. It contains an amino terminal C2 domain and 2 WW domains that are responsible for cellular localization and substrate recognition, and a catalytic carboxyl terminal HECT domain.
Smurf1 was originally identified as a negative regulator of the TGF-β/BMP (bone morphogenetic proteins) signalling pathway by degrading SMAD proteins and TGF-β /BMP receptors. To date, over a dozen substrates have been identified, including Runx2, MEKK2, RhoA, Par6, JunB, Talin head, Prickle1, TRAF family proteins, and STAT1. This suggests a pleiotropic role for Smurf1 in various cellular functions such as bone homeostasis, embryonic development, cell movement and polarity control, and immune response. Aberrant expression of Smurfs has been shown to occur in several types of cancers, including breast, oesophageal, pancreatic and renal cell carcinomas.
Product Information
Quality LevelMQ100
Applications
Key Applications
  • Enzyme Assays
Biological Information
Cascade ComponentE3
Entrez Gene Number
Purification MethodPurified using glutathione sepharose.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Packaging Information
Material Size250 µg
Global Trade Item Number
Catalogue Number GTIN
23-058M 04053252936807