Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

573132 STAT3 Inhibitor XVIII, BP-1-102 - Calbiochem

573132
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
1334493-07-0C₂₉H₂₇F₅N₂O₆S

Products

Catalogue NumberPackaging Qty/Pack
573132-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable, orally bioavailable amidosalicylic acid compound that selectively binds the three subpockets of Stat3 SH2 domain surface (KD = 504 nM) and blocks Stat3 phosphorylation, dimerization, and DNA-binding activity in a dose-dependent manner. Preferentially disrupts the high affinity binding between Stat3 and IL-6R/gp130-derived pTyr904 peptide (IC50 = 4.1 µM). Does not exert any significant effect on the phosphorylation status of Shc, Src, JAK1/2, Erk1/2, or Akt. Shown to reduce Stat3-dependent growth, survival, migration, and invasion of tumor cells in vitro and suppress the growth of aberrant Stat3-harboring human breast and lung tumor xenografts (3 mg/kg, i,v. or o.g.) in vivo.
Catalogue Number573132
Brand Family Calbiochem®
Synonyms4-(N-(4-Cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid
References
ReferencesZhang, X., et al. Proc. Natl. Acad. Sci. USA 109, 9623.
Product Information
CAS number1334493-07-0
FormWhite powder
Hill FormulaC₂₉H₂₇F₅N₂O₆S
Chemical formulaC₂₉H₂₇F₅N₂O₆S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSTAT3 Inhibitor XVIII, BP-1-102, CAS 1334493-07-0, binds to the three subpockets of STAT3 SH2 domain and blocks STAT3 phosphorylation, dimerization, and DNA-binding activity.
Biological Information
Primary TargetStat3
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
573132-10MG 04055977189513