554995 Sigma-AldrichRGS Proteins Inhibitor II, CCG-50014 - Calbiochem
The RGS Proteins Inhibitor II, CCG-50014 controls the biological activity of RGS4 proteins. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The RGS Proteins Inhibitor II, CCG-50014 controls the biological activity of RGS4 proteins. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<Synonyms: 4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione
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Overview
Key Spec Table
Empirical Formula |
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C₁₆H₁₃FN₂O₂S |
Products
Catalogue Number | Packaging | Qty/Pack | |
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554995-10MG | Glass bottle | 10 mg |
Description | |
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Overview | A cell-permeable thiadiazolidinedione compound that acts as a direct, potent, selective and cysteine-reactive irreversible inhibitor of RGS4 over other RGS proteins (IC50 = 0.03, 0.12, 3.5, 11, > 200 and > 200 µM against RGS4, RGS19, RGS16, RGS8, RGS7 and RGS4Cys− using FCPIA assay, respectively). Shown to block RGS4-Gα0 interaction and repress Gα0-dependent membrane localization of RGS4 in HEK-293T cells with no effect on the intrinsic rate of GTP hydrolysis by Gα0. Suggested to interact with Cys107-RGS8 allosteric regulatory site and display minimal affinity towards papain (IC50 > 100 µM). A reversible inhibitor of RGS Proteins, CCG-63802 is also available (Cat. No. 554993). |
Catalogue Number | 554995 |
Brand Family | Calbiochem® |
Synonyms | 4-(4-Fluorobenzyl)-2-p-tolyl-1,2,4-thiadiazolidine-3,5-dione |
References | |
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References | Blazer, L.L., et al. 2011. Biochemistry 50, 3181. Roman, D.L., et al. 2009. J. Biomol. Screening 14, 610. |
Product Information | |
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Form | White solid |
Hill Formula | C₁₆H₁₃FN₂O₂S |
Chemical formula | C₁₆H₁₃FN₂O₂S |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Purity | ≥98% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
554995-10MG | 04055977268362 |