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553030 RAGE Antagonist, FPS-ZM1 - CAS 945714-67-0 - Calbiochem

RAGE Antagonist, FPS-ZM1, is a blood-brain-barrier permeant blocker of RAGE V domain-mediated ligand binding (Ki = 25, 148, & 230 nM, respectively, against Aβ40, HMGB1 & S100B, binding to sRAG

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Synonyms: N-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1

Primary Target: RAGE
553030
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Overview

Key Spec Table

CAS #Empirical Formula
945714-67-0C₂₀H₂₂ClNO

Products

Catalogue NumberPackaging Qty/Pack
553030-25MG Glass bottle 25 mg
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Description
OverviewA blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230 nM, respectively, against Aβ40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Aβ40 and Aβ42 into the brain. Also shown to suppress Aβ-RAGE induced NF-κB activation and NF-κB-dependent transcription of β-secretase. Daily treatment of APPsw/0 murine AD model (1 mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice.
Catalogue Number553030
Brand Family Calbiochem®
SynonymsN-Benzyl-4-chloro-N-cyclohexylbenzamide, Receptor for AGE Antagonist, FPS-ZM1
References
ReferencesDeane, R., et al. 2012. J. Clin. Invest. 122, 1377.
Product Information
CAS number945714-67-0
FormWhite to off-white semi-solid or viscous liquid
Hill FormulaC₂₀H₂₂ClNO
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetRAGE
Primary Target K<sub>i</sub>25, 148, and 230 nM, respectively, against A&beta
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
553030-25MG 04055977193466