553510 Sigma-AldrichRAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem
A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis.
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Synonyms: 3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide, RS-1
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 312756-74-4 | C₂₀H₁₆Br₂N₂O₃S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 553510-10MG | Plastic ampoule | 10 mg |
| Description | |
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| Overview | A cell-permeable sulfonamido-benzamide-based allosteric regulator that stimulates DNA binding and recombinase activities of hRAD51 by locking hRAD51 in an active conformation without affecting its active site ATP hydrolysis. Although RS-1 enhances hRAD51 filament formation on ssDNA with or without the cofactor NTP, active filaments and recombinase activity are only induced in the presence of ATP or AMP-PNP, but not with ADP or no cofactors. Shown to promote resistance of primary human neonatal dermal fibroblasts to Cisplatin- (Cat. No. 232120) induced death in a dose-dependent manner. RS-1 is inactive toward related DNA strand exchange proteins scRAD5 and scDMC1 of yeast origin or E. coli RedA.This HDR (homology-directed repair) enhancer, is shown to significantly increase both Cas9 & TALEN-mediated knock-in efficiencies. |
| Catalogue Number | 553510 |
| Brand Family | Calbiochem® |
| Synonyms | 3-((Benzylamino)sulfonyl)-4-bromo-N-(4-bromophenyl)-benzamide, RS-1 |
| References | |
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| References | Song, J., et al. 2016. Nat. Comm., In Press. Jayathilaka, K., et al. 2008. Proc. Natl. Acad. Sci. USA. 105, 15848. |
| Product Information | |
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| CAS number | 312756-74-4 |
| Form | Light beige solid |
| Hill Formula | C₂₀H₁₆Br₂N₂O₃S |
| Chemical formula | C₂₀H₁₆Br₂N₂O₃S |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 553510-10MG | 04055977193695 |
Documentation
RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem SDS
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RAD51-Stimulatory Compound-1, RS-1 - CAS 312756-74-4 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 553510 |
References
| Reference overview |
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| Song, J., et al. 2016. Nat. Comm., In Press. Jayathilaka, K., et al. 2008. Proc. Natl. Acad. Sci. USA. 105, 15848. |