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528180 Plasminogen, Glu-Type, Human Plasma

Plasminogen, Glu-Type, Human Plasma MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
528180
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
528180-1MG Plastic ampoule 1 mg
Description
OverviewNative Glu-type plasminogen from human plasma. Plasminogen is a single chain glycoprotein found in normal plasma at ~12 mg per deciliter, and is the inactive precursor of the serine protease plasmin.
Catalogue Number528180
Brand Family Calbiochem®
References
ReferencesCollen, D. 1986. In Blood Coagulation (Zwaal, R.E.A., and Hemker, H.C. eds.) Elsevier, N.Y. p. 243.
Barlow, G.H., et al. 1984. Biochemistry 23, 2384.
Wohl, R.C., et al. 1982. Thromb. Res. 27, 523.
Castellino, F.J., et al. 1981. Methods Enzymol. 80, 365.
Robbins, K.C. 1976. Methods Enzymol. 45, 257.
Product Information
FormLiquid
FormulationIn 100 mM NaCl, 50 mM Tris-HCl, pH 7.5.
Quality LevelMQ100
Applications
Biological Information
PuritySingle band by SDS-PAGE
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Physicochemical Information
ContaminantsPlasmin activity: none detected
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
528180-1MG 04055977196450

Documentation

Plasminogen, Glu-Type, Human Plasma SDS

Title

Safety Data Sheet (SDS) 

Plasminogen, Glu-Type, Human Plasma Certificates of Analysis

TitleLot Number
528180

References

Reference overview
Collen, D. 1986. In Blood Coagulation (Zwaal, R.E.A., and Hemker, H.C. eds.) Elsevier, N.Y. p. 243.
Barlow, G.H., et al. 1984. Biochemistry 23, 2384.
Wohl, R.C., et al. 1982. Thromb. Res. 27, 523.
Castellino, F.J., et al. 1981. Methods Enzymol. 80, 365.
Robbins, K.C. 1976. Methods Enzymol. 45, 257.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-May-2008 RFH
DescriptionNative Glu-type plasminogen from human plasma. Plasminogen is a single chain glycoprotein zymogen, which is synthesized in the liver and circulates in plasma at a concentration of approximately 2.4 µM. The plasminogen molecule contains 790 amino acids, 24 disulfide bridges, no free sulfhydryls, and 5 regions of internal sequence homology, known as kringles, between Lys77 and Arg560. These kringle regions are homologous to the kringle domains in t-PA, u-PA, and prothrombin. Native Glu-plasminogen is readily converted to Lys77-plasminogen by plasmin hydrolysis of the Lys76-Lys77 peptide bond. The plasminogen is converted to plasmin by cleavage at Arg540-Val561 by urokinase, streptokinase, or tissue plasminogen activator.
FormLiquid
FormulationIn 100 mM NaCl, 50 mM Tris-HCl, pH 7.5.
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
PuritySingle band by SDS-PAGE
ContaminantsPlasmin activity: none detected
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
Merck USA index14, 7521
ReferencesCollen, D. 1986. In Blood Coagulation (Zwaal, R.E.A., and Hemker, H.C. eds.) Elsevier, N.Y. p. 243.
Barlow, G.H., et al. 1984. Biochemistry 23, 2384.
Wohl, R.C., et al. 1982. Thromb. Res. 27, 523.
Castellino, F.J., et al. 1981. Methods Enzymol. 80, 365.
Robbins, K.C. 1976. Methods Enzymol. 45, 257.