506155 Sigma-AldrichPifithrin-μ - CAS 64984-31-2 - Calbiochem
Pifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL & Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53.
More>> Pifithrin-μ, CAS 64984-31-2, is a cell-permeable inhibitor of p53 interaction with Bcl-xL & Bcl-2. Inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Less<<Pifithrin-μ - CAS 64984-31-2 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Phenylacetylenylsulfonamide, Hsp70 Inhibitor I
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 64984-31-2 | C₈H₇NO₂S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 506155-10MG | Plastic ampoule | 10 mg |
| Description | |
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| Overview | A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions. |
| Catalogue Number | 506155 |
| Brand Family | Calbiochem® |
| Synonyms | Phenylacetylenylsulfonamide, Hsp70 Inhibitor I |
| References | |
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| References | Leu, J., et al. 2009. Mol. Cell 36, 15. Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474. |
| Product Information | |
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| CAS number | 64984-31-2 |
| ATP Competitive | N |
| Form | Off-white solid |
| Hill Formula | C₈H₇NO₂S |
| Chemical formula | C₈H₇NO₂S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
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| Primary Target | p53 interaction with Bcl-xL and Bcl-2 proteins |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Toxicological Information |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 506155-10MG | 04055977272253 |
Documentation
Pifithrin-μ - CAS 64984-31-2 - Calbiochem SDS
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Pifithrin-μ - CAS 64984-31-2 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 506155 |
References
| Reference overview |
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| Leu, J., et al. 2009. Mol. Cell 36, 15. Strom, E., et al. 2006. Nat. Chem. Biol. 2, 474. |
Brochure
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| p53 And Related Products |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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