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540216 PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem

540216
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Overview

Key Spec Table

CAS #Empirical Formula
1229246-07-4C₁₉H₁₀BrF₆NO₃S

Products

Catalogue NumberPackaging Qty/Pack
540216-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound's in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal).
Catalogue Number540216
Brand Family Calbiochem®
SynonymsProtein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII
References
ReferencesBhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6161.
Product Information
CAS number1229246-07-4
FormLight yellow powder
Hill FormulaC₁₉H₁₀BrF₆NO₃S
Chemical formulaC₁₉H₁₀BrF₆NO₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥95% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
540216-10MG 04055977268706