217721 Sigma-AldrichInSolution™ Cdk1 Inhibitor IV, RO-3306 - Calbiochem
The InSolution™ Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone, 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one
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Overview
Key Spec Table
| Empirical Formula |
|---|
| C₁₈H₁₃N₃OS₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 217721-2MG | Glass bottle | 2 mg |
| Description | |
|---|---|
| Overview | A cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki =2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. The solid form of this compound (Cat. No. 217699) is also available. |
| Catalogue Number | 217721 |
| Brand Family | Calbiochem® |
| Synonyms | 5-(6-Quinolinylmethylene)-2-((2-thienylmethyl)amino)-4(5H)-thiazolone, 5-(Quinolin-6-ylmethylene)-2-(thiophen-2-ylmethylamino)thiazol-4(5H)-one |
| References | |
|---|---|
| References | Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660. |
| Product Information | |
|---|---|
| Form | Liquid |
| Formulation | A 10 mM (2 mg/569 µL) solution of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699) in DMSO. |
| Hill Formula | C₁₈H₁₃N₃OS₂ |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Cdk1/B1 and Cdk1/A |
| Primary Target K<sub>i</sub> | 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, |
| Secondary target | Cdk2/E, PKCδ, and SGK |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 217721-2MG | 04055977202410 |