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658411 InSolution™ AG490 - Calbiochem

InSolution™ AG490 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI

658411
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₇H₁₄N₂O₃

Products

Catalogue NumberPackaging Qty/Pack
658411-5MG Plastic ampoule 5 mg
Description
Catalogue Number658411
Brand Family Calbiochem®
SynonymsJAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
References
ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
Eriksen, K.W., et al. 2001. Leukemia 15, 787.
Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
Meydan, N., et al. 1996. Nature 379, 645.
Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
Product Information
FormLiquid
FormulationA 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
Hill FormulaC₁₇H₁₄N₂O₃
Chemical formulaC₁₇H₁₄N₂O₃
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
658411-5MG 04055977261608

Documentation

InSolution™ AG490 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ AG490 - Calbiochem Certificates of Analysis

TitleLot Number
658411

References

Reference overview
Jaleel, M., et al. 2004. Biochemistry 43, 8247.
Eriksen, K.W., et al. 2001. Leukemia 15, 787.
Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
Meydan, N., et al. 1996. Nature 379, 645.
Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision20-November-2008 JSW
SynonymsJAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
DescriptionPotent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
FormLiquid
FormulationA 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₄N₂O₃
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
Toxicity Irritant
ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
Eriksen, K.W., et al. 2001. Leukemia 15, 787.
Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
Meydan, N., et al. 1996. Nature 379, 645.
Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.