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420351 ICMT Inhibitor II, FTPAT - CAS 1350561-58-8 - Calbiochem

The ICMT Inhibitor II, FTPAT controls the biological activity of ICMT.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (E)-methyl-3-((5-(4-(2-((1,1ʹ-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate

420351
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1350561-58-8C₂₆H₃₁N₃O₂S

Products

Catalogue NumberPackaging Qty/Pack
420351-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable triazolo-farnesylthiopropanoate compound that acts as a potent, reversible, and isoprenyl mimetic competitive inhibitor of isoprenylcysteine carboxyl methyltransferase activity (ICMT; IC50 = 800 nM; Ki = 400 nM). Shown to prevent K-Ras membrane localization in GFP-K-Ras transfected Jurkat T-cells. Exhibits selective toxicity towards wt-Icmt+/+ mouse embryonic fibroblasts (MEFs) over Icmt-/- MEFs (IC50 = 33 and >100 µM). Also shown to arrest the proliferation of PaTu-8902, a highly metastatic pancreatic cancer cells (IC50 = 8 µM).
Catalogue Number420351
Brand Family Calbiochem®
Synonyms(E)-methyl-3-((5-(4-(2-((1,1ʹ-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate
References
ReferencesBergman, J.A., et al. 2012. ACS Med. Chem. Lett. 3, 15.
Product Information
CAS number1350561-58-8
FormWhite solid
Hill FormulaC₂₆H₃₁N₃O₂S
Chemical formulaC₂₆H₃₁N₃O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
420351-10MG 04055977187526

Documentation

ICMT Inhibitor II, FTPAT - CAS 1350561-58-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ICMT Inhibitor II, FTPAT - CAS 1350561-58-8 - Calbiochem Certificates of Analysis

TitleLot Number
420351

References

Reference overview
Bergman, J.A., et al. 2012. ACS Med. Chem. Lett. 3, 15.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-July-2012 JSW
Synonyms(E)-methyl-3-((5-(4-(2-((1,1ʹ-biphenyl]-4-yl)ethyl)-1H-1,2,3-triazol-1-yl)-3-methylpent-2-en-1-yl)thio)propanoate
DescriptionA cell-permeable triazolo-farnesylthiopropanoate compound that acts as a potent, reversible, and isoprenyl mimetic competitive inhibitor of isoprenylcysteine carboxyl methyltransferase activity (ICMT; IC50 = 800 nM; Ki = 400 nM). Shown to prevent K-Ras membrane localization in GFP-K-Ras transfected Jurkat T-cells. Exhibits selective toxicity towards wt-Icmt+/+ mouse embryonic fibroblasts (MEFs) over Icmt-/- MEFs (IC50 = 33 and >100 µM). Also shown to arrest the proliferation of PaTu-8902, a highly metastatic pancreatic cancer cells (IC50 = 8 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1350561-58-8
Chemical formulaC₂₆H₃₁N₃O₂S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBergman, J.A., et al. 2012. ACS Med. Chem. Lett. 3, 15.