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385920 HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem

The HSP90 Inhibitor, CCT018159, also referenced under CAS 171009-07-7, controls the biological activity of HSP90.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol

385920
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
171009-07-7C₂₀H₂₀N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
385920-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme's N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
Catalogue Number385920
Brand Family Calbiochem®
Synonyms4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
References
ReferencesHardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112.
Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206.
Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628.
Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212.
Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.
Product Information
CAS number171009-07-7
FormWhite solid
Hill FormulaC₂₀H₂₀N₂O₄
Chemical formulaC₂₀H₂₀N₂O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 24/25-36/37/39

Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
385920-5MG 04055977189841

Documentation

HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

HSP90 Inhibitor, CCT018159 - CAS 171009-07-7 - Calbiochem Certificates of Analysis

TitleLot Number
385920

References

Reference overview
Hardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112.
Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206.
Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628.
Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212.
Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-March-2008 JSW
Synonyms4-(4-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methyl-1H-pyrazol-3-yl)-6-ethylresorcinol
DescriptionA cell-permeable pyrazoloresorcinol compound that inhibits HSP90 ATPase activity (IC50 = 3.2 µM and 6.6 µM against human HSP90β and yeast HSP90, respectively) by targeting the enzyme's N-terminal ATP binding site. It exhibits no detectable effects against human Hsp70 or topoisomerase II even at concentrations as high as 100 µM and inhibits a panel of 20 commonly studied kinases only at much higher concentrations. Unlike 17-AAG (Cat. No. 100068), the antitumor activity of CCT018159 is not affected by the expression of NQ01/DT-diaphorase or P-glycoprotein.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number171009-07-7
Chemical formulaC₂₀H₂₀N₂O₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (35 mg/ml), H₂O (1.7 mg/ml) or Ethanol (35 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solution are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesHardcastle, A., et al. 2007. Mol. Cancer Ther. 6, 1112.
Sharp, S.Y., et al. 2007. Cancer Res. 67, 2206.
Smith, N.F., et al. 2006. Mol. Cancer Ther. 5, 1628.
Dymock, B.W., et al. 2005. J. Med. Chem. 48, 4212.
Cheung, K.M., et al. 2005. Bioorg. Med. Chem. Lett. 15, 3338.