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371970 HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem

A cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Fasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII

Primary Target: PKA
371970
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
103745-39-7C₁₄H₁₇N₃O₂S · 2HCl

Products

Catalogue NumberPackaging Qty/Pack
371970-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), and myosin light chain kinase (Ki = 36 µM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 µM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
Catalogue Number371970
Brand Family Calbiochem®
SynonymsFasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII
References
ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
Swärd, K., et al. 2000. J. Physiol. 522, 33.
Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
Seto, M., et al. 1991. Eur. J. Pharmacol. 195, 267.
Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther. 259, 738.
Asano, T., et al. 1990. Eur. J. Pharmacol. 190, 365.
Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun. 171, 1182.
Asano, T., et al. 1989. Br. J. Pharmacol. 98, 1091.
Product Information
CAS number103745-39-7
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₄H₁₇N₃O₂S · 2HCl
Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKA
Primary Target IC<sub>50</sub>10.7 µM inhibiting Rho-associated kinase (ROCK)
Primary Target K<sub>i</sub>.6 µM, 1.6 µM, 36 µM, inhibiting protein kinase A, protein kinase G, myosin light chain kinase, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 20/21/22

Harmful by inhalation, in contact with skin and if swallowed.
S PhraseS: 36

Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
371970-1MG 04055977213539

Documentation

HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

HA 1077, Dihydrochloride - CAS 103745-39-7 - Calbiochem Certificates of Analysis

TitleLot Number
371970

References

Reference overview
Watanabe, K., et al. 2007. Nature Biotech. 25, 681.
Swärd, K., et al. 2000. J. Physiol. 522, 33.
Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
Seto, M., et al. 1991. Eur. J. Pharmacol. 195, 267.
Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther. 259, 738.
Asano, T., et al. 1990. Eur. J. Pharmacol. 190, 365.
Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun. 171, 1182.
Asano, T., et al. 1989. Br. J. Pharmacol. 98, 1091.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-January-2010 RFH
SynonymsFasudil, (5-Isoquinolinesulfonyl)homopiperazine, 2HCl, PKG Inhibitor VII
DescriptionA cell-permeable, reversible, and ATP-competitive Ca2+ antagonist with anti-vasospastic properties. Inhibits protein kinase A (Ki = 1.6 µM), protein kinase G (Ki = 1.6 µM), and myosin light chain kinase (Ki = 3.6 µM). Also reported to potently inhibit Rho-associated kinase (ROCK; IC50 = 10.7 µM). Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency.
FormWhite solid
CAS number103745-39-7
Chemical formulaC₁₄H₁₇N₃O₂S · 2HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (1 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Aqueous stock solutions are stable for up to 6 months at 4°C.
Toxicity Harmful
ReferencesWatanabe, K., et al. 2007. Nature Biotech. 25, 681.
Swärd, K., et al. 2000. J. Physiol. 522, 33.
Takizawa, S., et al. 1993. Eur. J. Pharmacol. 250, 431.
Seto, M., et al. 1991. Eur. J. Pharmacol. 195, 267.
Shirotani, M., et al. 1991. J. Pharmacol. Exp. Ther. 259, 738.
Asano, T., et al. 1990. Eur. J. Pharmacol. 190, 365.
Sasaki, Y., and Sasaki, Y. 1990. Biochem. Biophys. Res. Commun. 171, 1182.
Asano, T., et al. 1989. Br. J. Pharmacol. 98, 1091.

Related Products & Applications

Categories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Rho Kinase (ROCK) Inhibitors