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368055 Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem

The Granzyme B Inhibitor II, also referenced under CAS 1258003-96-1, controls the biological activity of Granzyme B. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Caspase-8 Inhibitor I, Ac-IETD-CHO

Primary Target: caspase-8
368055
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1258003-96-1C₂₁H₃₄N₄O₁₀

Products

Catalogue NumberPackaging Qty/Pack
368055-1MG Plastic ampoule 1 mg
Description
OverviewA potent, reversible inhibitor of granzyme B and caspase-8 (Ki = 1 nM). Also inhibits caspase-1 (<6 nM), caspase-6 (5.6 nM), and caspase-10 (27 nM).
Catalogue Number368055
Brand Family Calbiochem®
SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
References
ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.
Product Information
CAS number1258003-96-1
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₁H₃₄N₄O₁₀
Chemical formulaC₂₁H₃₄N₄O₁₀
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-8
Primary Target K<sub>i</sub>1 nM against caspase-8
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
368055-1MG 04055977192131

Documentation

Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Granzyme B Inhibitor II - CAS 1258003-96-1 - Calbiochem Certificates of Analysis

TitleLot Number
368055

References

Reference overview
Gao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
SynonymsCaspase-8 Inhibitor I, Ac-IETD-CHO
DescriptionPotent, reversible granzyme B and caspase-8 inhibitor.
FormWhite lyophilized solid
CAS number1258003-96-1
Chemical formulaC₂₁H₃₄N₄O₁₀
Peptide SequenceAc-Ile-Glu-Thr-Asp-CHO
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGao, C.F., et al. 2001. Exp. Cell. Res. 265, 145.
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Han, Z., et al. 1997. J. Biol. Chem. 272, 13422.