Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

353905 Glutathione Monoethyl Ester - CAS 118421-50-4 - Calbiochem

Cell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: γ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE

353905
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
118421-50-4C₁₂H₂₁N₃O₆S

Products

Catalogue NumberPackaging Qty/Pack
353905-50MG Glass bottle 50 mg
Description
OverviewCell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases to release GSH. Effective transport of GSH-MEE has been used to protect cells against damage from radiation, oxidants, and various toxic compounds including heavy metals. A protective agent against cellular damage such as in cataracts and mitochondrial degeneration.
Catalogue Number353905
Brand Family Calbiochem®
Synonymsγ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE
References
ReferencesGrattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.
Product Information
CAS number118421-50-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₂H₂₁N₃O₆S
Chemical formulaC₁₂H₂₁N₃O₆S
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetEffective transport of GSH-MEE
Purity>90% by TLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
353905-50MG 04055977193244

Documentation

Glutathione Monoethyl Ester - CAS 118421-50-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Glutathione Monoethyl Ester - CAS 118421-50-4 - Calbiochem Certificates of Analysis

TitleLot Number
353905

References

Reference overview
Grattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress

Citations

Title
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-July-2007 RFH
    Synonymsγ-GCE, L-γ-Glutamyl-L-cysteinyl Ethyl Glycinate, GSH-MEE
    DescriptionCell-permeable derivative of glutathione (GSH) that undergoes hydrolysis by intracellular esterases thereby increasing intracellular GSH concentration in many tissues and cell types. Effective transport of GSH-MEE has been used to protect cells against radiation damage, oxidants and various toxic compounds including heavy metals. A protective agent against cellular damage, such as cataracts and mitochondrial degeneration.
    FormWhite solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number118421-50-4
    Chemical formulaC₁₂H₂₁N₃O₆S
    Structure formulaStructure formula
    Purity>90% by TLC
    SolubilityH₂O (50 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Unstable in solution; reconstitute just prior to use.
    Toxicity Standard Handling
    ReferencesGrattagliano, I., et al. 1995. J. Pharmacol. Exp. Ther. 272, 484.
    Martensson, J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 317.
    Anderson, M.E., and Meister, A. 1989. Anal. Biochem. 183, 16.
    Anderson, M.E., et al. 1985. Arch. Biochem. Biophys. 239, 538.
    Wellner, V.P., et al. 1984. Proc. Natl. Acad. Sci. USA 81, 4732.
    Puri, R.N., and Meister, A. 1983. Proc. Natl. Acad. Sci. USA 80, 5258.
    Citation
  • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
    		•