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343020 Flt-3 Inhibitor - CAS 301305-73-7 - Calbiochem

343020
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Overview

Key Spec Table

CAS #Empirical Formula
301305-73-7C₁₈H₂₀N₂O₄S

Products

Catalogue NumberPackaging Qty/Pack
343020-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable thienylcarboxamide compound that acts as a potent, ATP-competitive, and highly selective Flt-3 inhibitor (IC50 = 42 nM) with little effect against a panel of 22 other kinases (IC50 ≥3 µM). Shown to exhibit antiproliferative properties against the human acute myelogenous leukemia cell line MV4-11 (IC50 = 340 nM) expressing constitutively active Flt-3.
Catalogue Number343020
Brand Family Calbiochem®
References
ReferencesPatch, R.J., et al. 2006. Bioorg. Med. Chem. Lett. 16, 3282.
Product Information
CAS number301305-73-7
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₈H₂₀N₂O₄S
Chemical formulaC₁₈H₂₀N₂O₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetFlt-3
Primary Target IC<sub>50</sub>42 nM against Flt-3
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
343020-5MG 04055977195019