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324693 Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem

Principal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl

Primary Target: Movement of ribosomes along the mRNA
324693
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
316-42-7C₂₉H₄₀N₂O₄ · 2HCl

Products

Catalogue NumberPackaging Qty/Pack
324693-250MG Alu drum 250 mg
Description
OverviewPrincipal alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Interferes with cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
Catalogue Number324693
Brand Family Calbiochem®
Synonyms6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
References
ReferencesKong, H.S., et al. 2010. Mol. Pharmacol. in press.
Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
Kokuho, T., et al. 1995. Immunobiology 193, 42.
Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
Landis, R.C., et al. 1991. J. Immunol. 146, 128.
Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
Product Information
CAS number316-42-7
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₉H₄₀N₂O₄ · 2HCl
Chemical formulaC₂₉H₄₀N₂O₄ · 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMovement of ribosomes along the mRNA
Primary Target IC<sub>50</sub>≤1 µM as a specific inhibitor of HIF-2α protein stability and transcriptional activity
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSJY5250000
Safety Information
R PhraseR: 28-36/38

Very toxic if swallowed.
Irritating to eyes and skin.
S PhraseS: 28-36/37-45


Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324693-250MG 04055977215885

Documentation

Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Emetine, Dihydrochloride - CAS 316-42-7 - Calbiochem Certificates of Analysis

TitleLot Number
324693

References

Reference overview
Kong, H.S., et al. 2010. Mol. Pharmacol. in press.
Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
Kokuho, T., et al. 1995. Immunobiology 193, 42.
Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
Landis, R.C., et al. 1991. J. Immunol. 146, 128.
Schweighoffer, T., et al. 1991. Histochemistry 96, 93.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2019 JSW
Synonyms6ʹ,7ʹ,10,11-Tetramethoxyemetan, 2HCl
DescriptionPrinciple alkaloid of ipecac, isolated from the ground roots of Uragoga ipecacuanha. Irreversibly blocks protein synthesis in eukaryotes by inhibiting the movement of ribosomes along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits cytometric analysis of DNA replication at the early S phase. Also identified as a specific inhibitor of HIF-2α protein stability and transcriptional activity (IC50 ≤1 µM.
FormWhite to off-white solid
CAS number316-42-7
RTECSJY5250000
Chemical formulaC₂₉H₄₀N₂O₄ · 2HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityEthanol or H₂O (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Highly Toxic
Merck USA index14, 3559
ReferencesKong, H.S., et al. 2010. Mol. Pharmacol. in press.
Khan, M.A. 1995. Prog. Neurobiol. 46, 541.
Kokuho, T., et al. 1995. Immunobiology 193, 42.
Lee, Y.S., and Wurster, R.D. 1995. Cancer Lett. 93, 157.
Burhans, W.C., et al. 1991. EMBO J. 10, 4351.
Filley, E.A., and Rook, G.A. 1991. Infect. Immun. 59, 2567.
Landis, R.C., et al. 1991. J. Immunol. 146, 128.
Schweighoffer, T., et al. 1991. Histochemistry 96, 93.