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317640 Dipeptidyl Peptidase IV (CD26), Porcine Kidney

317640
Purchase on Sigma-Aldrich

Overview

Products

Catalogue NumberPackaging Qty/Pack
317640-250MIU Plastic ampoule 250 miu
Description
OverviewNative, DPP IV purified from porcine kidney (renal brush border of the proximal tubule). A serine exopeptidase dimer composed of two identical subunits of 110-130 kDa. Cleaves Xaa-Pro dipeptides from the N-terminus of oligo and polypeptides. DPPIV is involved in many cellular processes such as activation of cytokines, differentiation, T cell activation, and cell-matrix interactions. Inhibition of DPPIV has been reported to be an effective treatment for type II diabetes. MW: ~210000-260000 (unreduced).
Catalogue Number317640
Brand Family Calbiochem®
SynonymsCD26, DPPIV
References
ReferencesBar, J., et al. 2003. Biol. Chem. 384, 1553.
Engel, M., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 5063.
Ikehara, Y., et al. 1994. Methods. Enzymol. 244, 215.
David, F., et al. 1993. J. Biol. Chem. 268, 17247.
Thomsen, P.D., et al. 1993. Mamm. Genome 4, 604.
Misumi, Y., et al. 1992. Biochim. Biophys. Acta. 1131, 333.
Seidl, R., et al. 1991. Biol. Chem. Hoppe Seyler 372, 213.
Checler, F., et al. 1985. J. Neurochem. 45, 1509.
Imai, K., et al. 1983. J. Biochem. 93, 431.
Kato, T., et al. 1979. Experientia. 35, 409.
Kojima, K., et al. 1979. Anal. Biochem. 100, 43.
Kato, T., et al. 1978. Biochem. Med. 19, 351.
Kenny, A.J., et al. 1976. Biochem. J. 157, 169.
Product Information
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmole 7-(Gly-Pro)-amino-4-methylcoumarinamide per min at 37°C, pH 8.5.
EC number3.4.14.5
FormLiquid
FormulationIn 20 mM Tris-HCl, 5 mM CaCl₂, 1 µM ZnCl₂, 0.05% NaN₃, pH 8.0.
Quality LevelMQ100
Biological Information
Purity≥90% by SDS-PAGE
Specific Activity≥35 units/mg protein
Concentration Label Please refer to vial label for lot-specific concentration
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsDilute only the amount of enzyme needed for each assay. Upon thawing, do not re-freeze, store in the refrigerator (4°C).
Global Trade Item Number
Catalogue Number GTIN
317640-250MIU 04055977216257