239803 Sigma-AldrichCyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem
Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo.
More>> Cyclopamine, V. californicum, CAS 4449-51-8, is a cell-permeable steroidal alkaloid & cholesterol mimic that specifically antagonizes Sonic Hedgehog signaling through direct interaction with Smo. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Shh Signaling Antagonist I
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 4449-51-8 | C₂₇H₄₁NO₂ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 239803-1MG | Glass bottle | 1 mg | |
| 239803-5MG | Glass bottle | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10 mM solution in Ethanol (Cat. No. 239806). |
| Catalogue Number | 239803 |
| Brand Family | Calbiochem® |
| Synonyms | Shh Signaling Antagonist I |
| Product Information | |
|---|---|
| CAS number | 4449-51-8 |
| ATP Competitive | N |
| Form | Off-white solid |
| Hill Formula | C₂₇H₄₁NO₂ |
| Chemical formula | C₂₇H₄₁NO₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Hh signaling in Shh-light2 assay |
| Primary Target IC<sub>50</sub> | 20 nM |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Safety Information according to GHS | |
|---|---|
| RTECS | GY0750000 |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 239803-1MG | 04055977198867 |
| 239803-5MG | 04055977198874 |