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238590 Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem

Cucurbitacin I, Cucumis sativus L., CAS 2222-07-3, is a cell-permeable anti-proliferative agent that acts as a potent and highly selective inhibitor of JAK/STAT3 signaling pathway.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: JSI-124, STAT3 Inhibitor XIV

Primary Target: JAK/STAT3
238590
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2222-07-3C₃₀H₄₂O₇

Products

Catalogue NumberPackaging Qty/Pack
238590-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. It suppresses STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt, Erk1/2, or JNK.
Catalogue Number238590
Brand Family Calbiochem®
SynonymsJSI-124, STAT3 Inhibitor XIV
References
ReferencesBlaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.
Product Information
CAS number2222-07-3
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₀H₄₂O₇
Chemical formulaC₃₀H₄₂O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCucurbitacin I, Cucumis sativus L., CAS 2222-07-3, is a cell-permeable anti-proliferative agent that acts as a potent and highly selective inhibitor of JAK/STAT3 signaling pathway.
Biological Information
Primary TargetJAK/STAT3
Primary Target IC<sub>50</sub>500 nM suppressing STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRC6200000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
238590-1MG 04055977216592

Documentation

Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem Certificates of Analysis

TitleLot Number
238590

References

Reference overview
Blaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-April-2011 JSW
SynonymsJSI-124, STAT3 Inhibitor XIV
DescriptionA cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that exhibits anti-proliferative and anti-tumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/Signal transducer and activator of transcription 3 (Jak/STAT3) signaling pathway. Reported to suppress STAT3 tyrosine phosphorylation in v-src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Also shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt1, ERK1/2, or JNK.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number2222-07-3
RTECSRC6200000
Chemical formulaC₃₀H₄₂O₇
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBlaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.