233624 Sigma-AldrichCryptocrome Activator, KL001 - CAS 309928-48-1 - Calbiochem
The Cryptocrome Activator, KL001 modulates the biological activity of Cryptocrome. This small molecule/inhibitor is primarily used for Biochemicals applications.
More>> The Cryptocrome Activator, KL001 modulates the biological activity of Cryptocrome. This small molecule/inhibitor is primarily used for Biochemicals applications. Less<<Synonyms: N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide, CRY Activator, KL001
Overview
Products
Catalogue Number | Packaging | Qty/Pack | |
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233624-25MG | Glass bottle | 25 mg |
Description | |
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Overview | A cell-permeable carbazole compound that competes against FAD (flavin adenine dinucleotide) for cryptocrome (CRY) 1 & 2 binding, displaying little affinity toward other clock proteins (PER1/2, CLOCK, or BMAL1) or inhibitory activity against casein kinase (CKIα, CKIδ, and CK2) activity even at concentrations as high as 100 µM. Shown to selectively stabilize cellular CRY1/2 protein, but not mRNA, by preventing FBXL3-mediated CRY1/2 ubiquitination and proteasomal degradation, effectively lengthening the period and reducing the amplitude of the circadian transcription rhythms of Bmal1 and Per2 promoter-mediated transcription activity (IC50 of intensity reduction = 14 and 0.82 µM, respectively, in U2OS reporter assay). KL001 is also reported to block glucagon-induced Pck1 and G6pc mRNA upregulation as well as glucose production in primary murine hepatocyte cultures (IC50 <8 µM). Longdaysin (Cat. No. 438075), in comparison, exerts its circadian perturbation activity via casein kinase inhibition. |
Catalogue Number | 233624 |
Brand Family | Calbiochem® |
Synonyms | N-(3-(9H-Carbazol-9-yl)-2-hydroxypropyl)-N-(furan-2-ylmethyl)methanesulfonamide, CRY Activator, KL001 |
References | |
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References | Hirota, T., et al. 2012. Science 337, 1094. |
Product Information | |
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CAS number | 309928-48-1 |
Form | Off-white solid |
Hill Formula | C₂₁H₂₂N₂O₄S |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ100 |
Biological Information | |
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Primary Target | Cryptocrome protein |
Purity | ≥98% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
233624-25MG | 04055977217919 |