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219502 Cathepsin L Inhibitor, CAA0225 - Calbiochem

219502
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Overview

Key Spec Table

Empirical Formula
C₂₈H₂₉N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
219502-1MG 1 mg
Description
OverviewAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
Catalogue Number219502
Brand Family Calbiochem®
References
ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
Ueno, T., et al. 2009. Autophagy 5, 878.
Product Information
FormWhite solid
Hill FormulaC₂₈H₂₉N₃O₅
Chemical formulaC₂₈H₂₉N₃O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Purity≥ 95% by HPLC
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
219502-1MG 04055977218039