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236015 COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem

The COX-2 Inhibitor V, FK3311, also referenced under CAS 116686-15-8, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide

236015
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
116686-15-8C₁₅H₁₃F₂NO₄S

Products

Catalogue NumberPackaging Qty/Pack
236015-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
Catalogue Number236015
Brand Family Calbiochem®
Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
References
ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
Product Information
CAS number116686-15-8
FormWhite solid
Hill FormulaC₁₅H₁₃F₂NO₄S
Chemical formulaC₁₅H₁₃F₂NO₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
236015-5MG 04055977217155

Documentation

COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

COX-2 Inhibitor V, FK3311 - CAS 116686-15-8 - Calbiochem Certificates of Analysis

TitleLot Number
236015

References

Reference overview
Otani, Y., et al. 2007. J. Invest. Surg. 20, 175.
Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-March-2009 RFH
Synonyms4ʹ-Acetyl-2ʹ-(2,4-Difluorophenoxy)methanesulfonanilide
DescriptionA cell-permeable and orally available sulfonanilide that acts as a COX-2-selective non-steroidal anti-inflammatory drug (NSAID). Shown to exhibit 500-fold greater potency in inhibiting the LPS-induced (IC50 = 316 nM in human mononuclear cells) than the non-induced/constitutive (IC50 = 160 µM in human platelets) TxB2 production in vitro and effectively alleviate warm ischemia-reperfusion injury in the canine liver and rat lung in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number116686-15-8
Chemical formulaC₁₅H₁₃F₂NO₄S
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (30 mg/ml) or Ethanol (15 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesOtani, Y., et al. 2007. J. Invest. Surg. 20, 175.
Sunose, Y., et al. 2001. Transplant Proc. 33, 862.
Grossman, C.J., et al. 1995. Inflamm. Res. 44, 253.
Nakamura, K., et al. 1993. Chem. Pharm. Bull. 41, 2050.
Tsuji, K., et al. 1992. Chem. Pharm. Bull. 40, 2399.