205530 Sigma-AldrichCA-074 - Calbiochem
CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> CA-074, also referenced under CAS 134448-10-5, modulates the biological activity of cathepsin B. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<CA-074 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Cathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline
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Overview
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Key Spec Table
| Empirical Formula |
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| C₁₈H₂₉N₃O₆ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 205530-1MG | Plastic ampoule | 1 mg |
| Description | |
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| Overview | An epoxysuccinyl peptide that acts as a potent, irreversible, and specific inhibitor of cathepsin B (IC50 = 2.24 nM for rat liver cathepsin B). Reduces ischemia-induced neuronal death. Exhibits lower membrane permeability when compared to CA-074 Me (Cat. No. 205531). |
| Catalogue Number | 205530 |
| Brand Family | Calbiochem® |
| Synonyms | Cathepsin B Inhibitor III, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline |
| Product Information | |
|---|---|
| ATP Competitive | N |
| Form | Colorless or white solid |
| Hill Formula | C₁₈H₂₉N₃O₆ |
| Chemical formula | C₁₈H₂₉N₃O₆ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | cathepsin B |
| Primary Target IC<sub>50</sub> | 2.24 nM for rat liver cathepsin B |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Safety Information according to GHS |
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| Safety Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 205530-1MG | 04055977219616 |
Documentation
CA-074 - Calbiochem SDS
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CA-074 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 205530 |
References
| Reference overview |
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| Chan, V.J., et al. 1999. Biochem. J. 340, 113. Tsuchiya, K., et al. 1999. Exp. Neurol. 155, 187. Yamamoto, A., et al. 1997. J. Biochem. 121, 974. Inubushi, T., et al. 1994. J. Biochem. 116, 282. Murata, M., et al. 1991. FEBS Lett. 280, 307. Towatari, T., et al. 1991. FEBS Lett. 280, 311. |