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189406 Aurora Kinase/Cdk Inhibitor - CAS 443797-96-4 - Calbiochem

189406
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Overview

Key Spec Table

CAS #Empirical Formula
443797-96-4C₁₅H₁₂F₂N₆O₃S • CH₃CN

Products

Catalogue NumberPackaging Qty/Pack
189406-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable triazolylsulfonamido compound that acts a reversible, ATP-competitive kinase inhibitor with selectivities towards Aurora kinases (IC50 = 11 and 15 nM for Aurora-A, Aurora-B, respectively) and Cdk's (IC50 = 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively). Displays antitumor properties both in vitro (IC50 in the range of 112 - 514 nM against various human cancer cell lines) and in a xenograft murine model in vivo (75-100 mg/kg, i.p.).
Catalogue Number189406
Brand Family Calbiochem®
Synonyms4-(5-Amino-1-(2,6-difluorobenzoyl)-1H-[1,2,4]triazol-3-ylamino)-benzenesulfonamide, Aurora Kinase Inhibitor I, JNJ-7706621
References
ReferencesEmanuel, S., et al. 2005. Cancer Res. 65, 9038.
Lin R., et al. 2005. J. Med. Chem. 48, 4208.
Product Information
CAS number443797-96-4
ATP CompetitiveY
FormWhite solid
Hill FormulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
Chemical formulaC₁₅H₁₂F₂N₆O₃S • CH₃CN
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetAurora Kinase/Cdk
Primary Target IC<sub>50</sub>11 and 15 nM for Aurora-A, Aurora-B, respectively; 9, 4, and 3 nM for Cdk1/B, Cdk2/A, and Cdk2/E, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
189406-5MG 04055977221756