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ABN426 Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody

This Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody is validated for use in Western Blotting for the detection of phospho-Neurogranin (Ser36)/Neuromodulin (Ser41).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neuroregenerative Medicine Gene Symbol: Nrgn, neurogranin, Ng, Neurogranin, hng, RC3 UniProt Number: Q04940
ABN426
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
MWBRbSerumPolyclonal Antibody
Description
Catalogue NumberABN426
DescriptionAnti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody
Alternate Names
  • Protein kinase C substrate 7.5 kDa protein RC3
Background InformationNeurogranin (Ng) (also named RC3, p17 or BICKS) is a small protein originally identified in rat brain and abundantly expressed in several telencephalic areas, such as the cerebral cortex, hippocampus, amygdala, and striatum. In neurons, it is found concentrated at dendritic spines where it participates in synaptic signaling events through the regulation of calmodulin (CaM). Neurogranin protein is a critical third messenger and substrate of PKC in the molecular cascade necessary for synaptic development and remodeling. Neurogranin (Ng) features an IQ motif that mediates its interaction with CaM and phosphatidic acid (PA). The interaction is controlled by phosphorylation at serine 36 of Neurogranin. Neurogranin is phosphorylated at serine 36 by PKC. Ser36-phosphorylated Neurogranin is unable to bind either CaM or PA. Neurogranin in localized in the cell bodies of neurons in the cortex and in the apical and basal dendrites of pyramidal neurons. Neurogranin is not found in dendrites and its expression is very low as well in Alzheimer’s disease patients.
References
Product Information
FormatSerum
PresentationRabbit Polyclonal serum with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody is validated for use in Western Blotting for the detection of phospho-Neurogranin (Ser36)/Neuromodulin (Ser41).
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the IQ domain of Rat phospho-Neurogranin.
EpitopeIQ domain
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityPhosphorylated Neurogranin and Neuromodulin
Species Reactivity
  • Mouse
Species Reactivity NoteMouse. Predicted to react with Rat based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • Nrgn
  • neurogranin
  • Ng
  • Neurogranin
  • hng
  • RC3
Modifications
  • Phosphorylation
Purification MethodUnpurified
UniProt Number
Molecular Weight~43 kDa is phospho-Neuromodulin (GAP-43) and ~17 KD is phospho-Neurogranin. Uncharacterized band(s) may appear in some lysates.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in Mouse brain tissue lysate.

Western Blotting Analysis: A 1:1000 dilution of this antibody detected phospho-Neurogranin (Ser36) / Neuromodulin (Ser41) in 10 µg of Mouse brain tissue lysate treate with magnisium (lane1) or PKC (lane2)
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABN426 04053252983559

Documentation

Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) Antibody Certificates of Analysis

TitleLot Number
Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - Q2441540 Q2441540
Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - 3250988 3250988
Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - 3753303 3753303
Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - 3860261 3860261
Anti-phospho-Neurogranin (Ser36)/Neuromodulin (Ser41) - 3928110 3928110