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MABS178 Anti-STK39 Antibody, clone 5H7.1

Anti-STK39 Antibody, clone 5H7.1 is a highly specific mouse monoclonal antibody, that targets STK39 & has been tested in western blotting & IHC.

Anti-STK39 Antibody, clone 5H7.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Developmental Signaling Gene Symbol: STK39, SPAK UniProt Number: Q9UEW8
MABS178
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, IHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS178
DescriptionAnti-STK39 Antibody, clone 5H7.1
Alternate Names
  • STE20/SPS1-related proline-alanine-rich protein kinase
  • Ste-20-related kinase
  • DCHT
  • Serine/threonine-protein kinase 39
Background InformationSerine/threonine-protein kinase 39 (STK39), also known as STE20/SPS-1 related proline alanine-rich kinase (SPAK), is a member of the SPS1 subfamily of STE20 kinases. STK39 is also very highly conserved between species and has been shown to activate the p38 pathways. STK39 also has a caspase cleavage site and these two functions may mean that STK39 plays a role in stress-activated signaling. STK39 expression is up-regulated by androgens in LNCaP human prostate cancer cells and regulated and phosphorylated by WNK1, which controls the stress signaling pathway. It is activated by WNK4 and then has the ability to stimulate the Na-K-2Cl cotransporter, the inactive version does not possess this ability. Recent research has also made a connection between STK39 and regulation of blood pressure.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-STK39 Antibody, clone 5H7.1 is a highly specific mouse monoclonal antibody, that targets STK39 & has been tested in western blotting & IHC.
Key Applications
  • Western Blotting
  • Immunohistochemistry
Application NotesWestern Blotting Analysis: 1.0 µg/mL from a representative lot detected STK39 in 10 µg of mouse and rat brain tissue lysate.
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected STK39 in human cerebellum sections and rat hindbrain sections tissue.
Biological Information
ImmunogenGST-tagged recombinant protein corresponding to the C-terminus of human STK39.
EpitopeC-terminus
Clone5H7.1
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThis antibody recognizes the C-terminus of STK39.
IsotypeIgG1κ
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • STK39
  • SPAK
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~60 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected STK39 in 10 µg of human brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABS178 04053252927232

Documentation

Anti-STK39 Antibody, clone 5H7.1 SDS

Title

Safety Data Sheet (SDS) 

Anti-STK39 Antibody, clone 5H7.1 Certificates of Analysis

TitleLot Number
Anti-STK39, clone 5H7.1 - 3601745 3601745
Anti-STK39, clone 5H7.1 - 3824853 3824853
Anti-STK39, clone 5H7.1 - 4061827 4061827
Anti-STK39, clone 5H7.1 - 4116938 4116938
Anti-STK39, clone 5H7.1 - Q2279648 Q2279648
Anti-STK39, clone 5H7.1 -2894068 2894068
Anti-STK39, clone 5H7.1 Monoclonal Antibody 2933873
Anti-STK39, clone 5H7.1 Monoclonal Antibody 3149918
Anti-STK39, clone 5H7.1 Monoclonal Antibody 2981028