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AB9602 Anti-Plexin-A1 Antibody

This Anti-Plexin-A1 Antibody is validated for use in WB for the detection of Plexin-A1.

Anti-Plexin-A1 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Growth Cones & Axon Guidance Gene Symbol: PLXNA1, NOV, PLXN1, PLEXIN-A1, NOVP UniProt Number: Q9UIW2
AB9602
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB9602
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Plexin-A1 Antibody
References
Product Information
FormatAffinity Purified
PresentationAffinity purified immunoglobulin. Liquid in PBS containing 50% glycerol, 1 mg/mL BSA and 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationThis Anti-Plexin-A1 Antibody is validated for use in WB for the detection of Plexin-A1.
Key Applications
  • Western Blotting
Application NotesWestern blot: 1:1,000 on neonatal rat brain and COS-7 cells transfected with mouse Plexin-A1. The antibody reacts with the ~220 kDa protein. The suggested antibody diluent is PBS containing 5% non-fat milk and 0.04% Tween 20. Other bands may be present depending on the concentration of antibody and sample used.
Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenSynthetic peptide from the semaphorin domain of human plexin-A1.
HostRabbit
SpecificityPlexin-A1. The immunogen sequence has low homology with other plexin family members.
Species Reactivity
  • Human
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PLXNA1
  • NOV
  • PLXN1
  • PLEXIN-A1
  • NOVP
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q9UIW2 # Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity).
SIZE: 1896 amino acids; 211087 Da
SUBUNIT: Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2 (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
TISSUE SPECIFICITY: Detected in fetal brain, lung, liver and kidney.
SIMILARITY: SwissProt: Q9UIW2 ## Belongs to the plexin family. & Contains 4 IPT/TIG domains. & Contains 1 Sema domain.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB9602 04053252285912