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07-1397 Anti-PP-1G Antibody

Detect PP-1G using this Anti-PP-1G Antibody validated for use in WB.

Anti-PP-1G Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Kinases & Phosphatases Gene Symbol: PPP1CC, PP-1G, PPP1G UniProt Number: P36873
07-1397
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBRbSerumPolyclonal Antibody
Description
Catalogue Number07-1397
DescriptionAnti-PP-1G Antibody
Alternate Names
  • Protein phosphatase 1C catalytic subunit
  • protein phosphatase 1, catalytic subunit, gamma isoform
  • serine/threonine phosphatase 1 gamma
Background InformationProtein phosphatase 1, gamma 1 (PP-1G) is a member of the PPP phosphatase family. Type 1 protein Ser/Thr phosphatases (PP1) have a high specific activity against phosphorylase, and are resistant to okadaic acid up to concentrations of 50 nM, but sensitive to Inhibitor-2 and microcystin LR.
References
Product Information
FormatSerum
Control
  • Mouse brain tissue lyste
PresentationUnpurified rabbit serum with 0.05% sodium azide.
Applications
ApplicationDetect PP-1G using this Anti-PP-1G Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human PP-1G.
EpitopeUnknown
HostRabbit
SpecificityThis antibody recognizes PP-1G.
Species Reactivity
  • Human
  • Mouse
  • Rat
Species Reactivity NoteProven to react with human and mouse. Predicted to react with rat based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PPP1CC
  • PP-1G
  • PPP1G
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II.

COFACTOR: Binds 1 iron ion per subunit. & Binds 1 manganese ion per subunit.

SIZE: 323 amino acids; 36984 Da

SUBUNIT: PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A and PPP1R12B mediate binding to myosin. PPP1R3A, PPP1R3B, PPP1R3C and PPP1R3D mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked. Interacts with PPP1R7. Isoform gamma-2 interacts with SPZ1 (By similarity). Interacts with CDCA2.

SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with SPZ1 in the nucleus (By similarity).

SIMILARITY: Belongs to the PPP phosphatase family. PP-1 subfamily.

MISCELLANEOUS: Microcystin toxin is bound to Cys-273 through a thioether bond.
Molecular Weight 37 kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in mouse brain tissue lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected PP-1G on 10 µg of mouse brain tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
07-1397 04053252474132