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MAB5782 Anti-NMDAR2B Antibody, NT

Detect NMDAR2B using this Anti-NMDAR2B Antibody, N-terminal validated for use in WB.

Anti-NMDAR2B Antibody, NT MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GRIN2B, MGC142180, Glutamate, NMDAR2B, NR3, NR2B, MGC142178, hNR3 UniProt Number: Q13224
MAB5782
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, R, Rb, FWBMAscitesMonoclonal Antibody
Description
Catalogue NumberMAB5782
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-NMDAR2B Antibody, NT
References
Product Information
FormatAscites
PresentationLiquid ascites fluid
Quality LevelMQ100
Applications
ApplicationDetect NMDAR2B using this Anti-NMDAR2B Antibody, N-terminal validated for use in WB.
Key Applications
  • Western Blotting
Application NotesWestern blot: 1:100-1:1,000 on rat brain lysate.

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenRecombinant protein from rat NMDAR2B.
Clone1A8.9B3
HostMouse
SpecificityNMDAR2B, N-terminal. By Western blot the antibody reacts with bands at ~170 kDa on rat brain lysate. Additional bands at ~116, 50 and 32 kDa may be seen depending on sample and antibody concentration used.
IsotypeIgG1
Species Reactivity
  • Human
  • Mouse
  • Rat
  • Rabbit
  • Fish
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryN-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
Gene Symbol
  • GRIN2B
  • MGC142180
  • Glutamate
  • NMDAR2B
  • NR3
  • NR2B
  • MGC142178
  • hNR3
Purification MethodAscites
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
SIZE: 1484 amino acids; 166367 Da
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB5782 04053252724466

Documentation

Anti-NMDAR2B Antibody, NT SDS

Title

Safety Data Sheet (SDS) 

Anti-NMDAR2B Antibody, NT Certificates of Analysis

TitleLot Number
MOUSE ANTI-NMDAR2B - 2211962 2211962
MOUSE ANTI-NMDAR2B - 3207606 3207606
MOUSE ANTI-NMDAR2B - 3583854 3583854
MOUSE ANTI-NMDAR2B - 3671745 3671745
MOUSE ANTI-NMDAR2B - 3715665 3715665
MOUSE ANTI-NMDAR2B - 3836460 3836460
MOUSE ANTI-NMDAR2B - 3979339 3979339
MOUSE ANTI-NMDAR2B - 4150383 4150383
MOUSE ANTI-NMDAR2B MONOCLONAL ANTIBODY 3778013
MOUSE ANTI-NMDAR2B MONOCLONAL ANTIBODY 3069870
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References

Reference overviewPub Med ID
Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies
Laurie, D J, et al
Brain Res Mol Brain Res, 51:23-32 (1997)  1997

9427503 9427503

Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer

Data Sheet

Title
MOUSE ANTI-NMDAR2B

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Alternative Packsize

Catalogue Number Description
MAB5782-KC Anti-NMDAR2B, NT, clone 1A8.9B3 (1mL) KC

Categories

Life Science Research > Antibodies and Assays > Primary Antibodies