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MAB4163 Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 detects level of MDR1 & has been published & validated for use in FC, IH, IH(P).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Metabolism Research Sub-Category: Toxicology & Drug Resistance Gene Symbol: ABCB1, PGY1, MGC163296, GP170, ABC20, CD243, P-gp, MDR1, CLCS, EC 3.6.3.44 UniProt Number: P08183
MAB4163
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFC, IHC, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB4163
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-MDR1 Antibody, extracellular human specific Pgp, clone MC57
Alternate Names
  • P-glycoprotein
  • CD243
  • p170
  • Pgp
References
Product Information
FormatPurified
PresentationPurified immunoglobulin from Protein A Sepharose chromatography. Liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% sodium azide.
Quality LevelMQ300
Applications
ApplicationAnti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 detects level of MDR1 & has been published & validated for use in FC, IH, IH(P).
Key Applications
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry (Paraffin)
Application NotesFlow Cytometry

Immunohistochemistry

Immunohistochemistry on paraffin sections

Functional Experiments

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenLiving intact human multidrug-resistant cells
Epitopeextracellular human specific Pgp
CloneMC57
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityMDR-1 clone MC57 recgonizes the inactivated form of Pgp and recognizes the conformational epitope in Immunohistochemistry on paraffin sections.
IsotypeIgG2aκ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
Gene Symbol
  • ABCB1
  • PGY1
  • MGC163296
  • GP170
  • ABC20
  • CD243
  • P-gp
  • MDR1
  • CLCS
  • EC 3.6.3.44
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P08183 # Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
SIZE: 1280 amino acids; 141463 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in liver, kidney, small intestine and brain.
SIMILARITY: SwissProt: P08183 ## Belongs to the ABC transporter family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. & Contains 2 ABC transmembrane type-1 domains. & Contains 2 ABC transporter domains.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at 2-8°C in undiluted aliquots for up to 6 months.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB4163 08436037125614

Documentation

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 SDS

Title

Safety Data Sheet (SDS) 

Anti-MDR1 Antibody, extracellular human specific Pgp, clone MC57 Certificates of Analysis

TitleLot Number
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3026850 3026850
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3434794 3434794
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3465453 3465453
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 3793697 3793697
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 4076647 4076647
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] - 4080473 4080473
MOUSE ANTI-MDR-1 [P-GLYCOPROTEIN] -2782551 2782551