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ABE1081 Anti-JMJD2E/KDM4E Antibody

Detect JMJD2E/KDM4E using this Anti-JMJD2E/KDM4E antibody validated for use in western blotting.

Anti-JMJD2E/KDM4E Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Chromatin Biology Gene Symbol: KDM4E, KDM4DL
ABE1081
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBRbSerumPolyclonal Antibody
Description
Catalogue NumberABE1081
DescriptionAnti-JMJD2E/KDM4E Antibody
Alternate Names
  • Lysine-specific demethylase 4E
  • KDM4D-like protein
  • Lysine-specific demethylase 4D-like
  • JMJD2E
Background InformationHistone N(ϵ)-methyl lysine demethylases are important in epigenetic regulation. JMJD2E (KDM4E) also known as Lysine-specific demethylase 4E, histone lysine demethylase 4E, or KDM4D-like protein, and encoded by the gene KDM4E/KDM4DL, is a member of the large Fe(II)/2-oxoglutarate- dependent family of human histone demethylases. JMJD2E (KDM4E) is a histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. The KDM4 family also includes KDM4A, KDM4B, KDM4C, and KDM4D. These are also referred to as JMDM3A/JMJD2A, JMDM3B/JMJD2B, JMDM3C/JMJD2C, and JMDM3D/JMJD2D, respectively. Steady-state assays showed that KDM4E has a graded response to O2 over a physiologically relevant range of O2 concentrations, with activity level being dependent upon the methylation status of the target protein, and research with JMJD2E(KDM4E) may indicate the potential for histone demethylase activity to be regulated by oxygen availability.
References
Product Information
FormatSerum
PresentationRabbit polyclonal serum containing 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect JMJD2E/KDM4E using this Anti-JMJD2E/KDM4E antibody validated for use in western blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenLinear peptide corresponding to JMJD2E/KDM4E.
HostRabbit
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • KDM4E
  • KDM4DL
Purification MethodUnpurified
Molecular Weight~65 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in PC-12 cell lysate.

Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected JMJD2E/KDM4E in 10 µg of PC-12 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABE1081 04053252944789