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AB1570 Anti-GABA Transporter-1 Antibody, CT (a.a. 588-599)

AB1570
10 µg  
Purchase on Sigma-Aldrich

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Overview

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, Mk, R, Rb, FeIHCRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB1570
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-GABA Transporter-1 Antibody, CT (a.a. 588-599)
Alternate Names
  • GAT-1
Product Information
FormatAffinity Purified
PresentationAffinity purified antibody. Lyophilized from in 0.1 M PBS with 1% BSA and 0.1% sodium azide. Reconstitute with 100 μL of sterile distilled water.
Quality LevelMQ100
Applications
ApplicationAnti-GABA Transporter-1 Antibody, C-terminus (a.a. 588-599) is an antibody against GABA Transporter-1 for use in IH.
Key Applications
  • Immunohistochemistry
Applications Not Recommended
  • Western Blotting
Application NotesImmunohistochemistry: 1:500-1:750 on 4% paraformaldehyde fixed or 4% paraformaldehyde and 0.2% glutaraldehyde fixed tissue. It is recommended that the antibody be diluted in PBS containing 10% normal goat serum and 0.5% Triton X-100. AB1570 has been used for both light and electron microscopic studies of rat retina, cortex and hippocampus.

Note: AB1570 is not recommended for Western blot use. See AB1570W.

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenRat GAT-1, C-terminus (aa 588-599)
EpitopeC-terminus (a.a. 588-599)
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityGABA Transporter-1 (GAT-1), C-terminus. No cross-reactivity to the C-termini of other transmitter transporters detected.
Species Reactivity
  • Human
  • Mouse
  • Monkey
  • Rat
  • Rabbit
  • Feline
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SLC6A1
  • GABATR
  • GAT1
  • GABATHG
  • GABT1
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P30531 # Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
SIZE: 599 amino acids; 67015 Da
SUBUNIT: Interacts with MPP5 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity).
DOMAIN: SwissProt: P30531 The PDZ domain-binding motif is involved in the interaction with MPP5.
SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) family.
MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain lyophilized material at 2-8°C for up to 12 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size10 µg
Global Trade Item Number
Catalogue Number GTIN
AB1570 04053252334696