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AB9742 Anti-14-3-3 σ Antibody

Anti-14-3-3 σ Antibody is an antibody against 14-3-3 σ for use in WB.

Anti-14-3-3 σ Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurodegenerative Diseases Gene Symbol: SFN, YWHAS, HME1, stratifin, Stratifin UniProt Number: P31947
AB9742
100 µL  
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Overview

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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
B, Ch, H, M, R, ShWBRbSerumPolyclonal Antibody
Description
Catalogue NumberAB9742
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-14-3-3 σ Antibody
Background InformationMammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer's.

The 14-3-3 sigma antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer's and Parkinson's Disease.
References
Product Information
FormatSerum
PresentationLiquid.
Quality LevelMQ100
Applications
ApplicationAnti-14-3-3 σ Antibody is an antibody against 14-3-3 σ for use in WB.
Key Applications
  • Western Blotting
Application NotesWestern blot: 1:3000

Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenSynthetic peptide from the N-terminal area of sheep 14-3-3 sigma.
HostRabbit
Specificity14-3-3 sigma. By Western blot the antibody recognizes the ~30 kDa protein.
Species Reactivity
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Sheep
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • SFN
  • YWHAS
  • HME1
  • stratifin
  • Stratifin
Purification MethodSerum
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P31947 # p53-regulated inhibitor of G2/M progression.
SIZE: 248 amino acids; 27774 Da
SUBUNIT: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). Secreted. Note=May be secreted by a non-classical secretory pathway.
TISSUE SPECIFICITY: Present mainly in tissues enriched in stratified squamous keratinising epithelium.
SIMILARITY: SwissProt: P31947 ## Belongs to the 14-3-3 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
AB9742 04053252674365

Documentation

Anti-14-3-3 σ Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-14-3-3 σ Antibody Certificates of Analysis

TitleLot Number
RABBIT ANTI-14-3-3 sigma - 2038235 2038235
RABBIT ANTI-14-3-3 sigma - 3277979 3277979

References

Reference overviewPub Med ID
Identification of 14-3-3 proteins in human platelets: effects of synthetic peptides on protein kinase C activation
Wheeler-Jones, C P, et al
Biochem J, 315 ( Pt 1):41-7 (1996)  1996

8670130 8670130

Data Sheet

Title
Anti-14-3-3 sigma - Data Sheet