Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

124008 Akt Inhibitor II - Calbiochem

Akt Inhibitor II, CAS 701976-54-7, is a cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt & downstream substrates.

Akt Inhibitor II - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: SH-5

Primary Target: Akt
124008
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₉H₅₉O₁₀P

Products

Catalogue NumberPackaging Qty/Pack
124008-1MG Plastic ampoule 1 mg
Description
OverviewA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and select downstream substrates without decreasing phosphorylation of PDK-1 or other kinases downstream of Ras, such as MAPK. Also acts as a potent inducer of apoptosis and selectively kills a variety of cancer cell lines that contain high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
Catalogue Number124008
Brand Family Calbiochem®
SynonymsSH-5
References
ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₉H₅₉O₁₀P
Chemical formulaC₂₉H₅₉O₁₀P
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationAkt Inhibitor II, CAS 701976-54-7, is a cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt & downstream substrates.
Biological Information
Primary TargetAkt
Purity≥98% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
124008-1MG 04055977206333

Documentation

Akt Inhibitor II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Akt Inhibitor II - Calbiochem Certificates of Analysis

TitleLot Number
124008

References

Reference overview
Gills, J.J., et al. 2007. J. Biol. Chem. in press.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.

Brochure

Title
Akt
Biologics 31.1
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-November-2009 RFH
SynonymsSH-5
DescriptionA cell permeable, reversible, and substrate competitive phosphatidylinositol analog that inhibits the activation of Akt and selected downstream substrates without affecting the phosphorylation of PDK-1 and other downstream kinases. Decreases phosphorylation of Akt without affecting the total Akt level. Reported to be a potent inducer of apoptosis and to selectively kill a variety of cancer cell lines expressing high levels of active Akt. When used at a concentration of 10 µM, it is reported to activate p38α/SAPK2α MAP kinase. At 10 µM it will also inhibit ~50% of PKA activity.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₉H₅₉O₁₀P
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO (10 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGills, J.J., et al. 2007. J. Biol. Chem. in press.
Kozikowski, A.P., et al. 2003. J. Am. Chem. Soc.125, 1144.