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426102 clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem

clasto-Lactacystin β-Lactone, CAS 154226-60-5, is a cell-permeable, highly specific, irreversible 20S proteasome inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Omuralide, Proteasome Inhibitor IX

Primary Target: 20S proteasome
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426102
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
154226-60-5C₁₀H₁₅NO₄

Pricing & Availability

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426102-100UG
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      		 Plastic ampoule 100 μg
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      Description
      OverviewA highly specific, cell-permeable, and irreversible 20S proteasome inhibitor. It is believed that in vitro, the natural product Lactacystin (Cat. No. 426100) acts as a precursor for clasto-lactacystin β-lactone and that the latter is the sole species that interacts with the proteasome.
      Catalogue Number426102
      Brand Family Calbiochem®
      SynonymsOmuralide, Proteasome Inhibitor IX
      References
      ReferencesCorey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
      Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
      Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
      Fenteany, G., et al. 1995. Science 268, 726.
      Product Information
      CAS number154226-60-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₅NO₄
      Chemical formulaC₁₀H₁₅NO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Applicationclasto-Lactacystin β-Lactone, CAS 154226-60-5, is a cell-permeable, highly specific, irreversible 20S proteasome inhibitor.
      Biological Information
      Primary Target20S proteasome
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      426102-100UG 04055977187366

      Documentation

      clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      clasto-Lactacystin β-Lactone - CAS 154226-60-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      426102

      References

      Reference overview
      Corey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
      Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
      Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
      Fenteany, G., et al. 1995. Science 268, 726.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Proteasomes Technical Bulletin

      Citations

      Title
    • Liguo Zhang, Kenneth P. Nephew and Patricia J. Gallagher. (2007) Regulation of death-associated protein kinase: stabilization by HSP90 heterocomplexes. Journal of Biological Chemistry 282, 11795-11804.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-February-2008 JSW
      SynonymsOmuralide, Proteasome Inhibitor IX
      DescriptionA cell-permeable, irreversible inhibitor of the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptide hydrolysis activities of the 20S proteasome. It is believed that in vitro, the natural product, Lactacystin (Cat. No. 426100), acts as a precursor for clasto-lactacystin β-lactone, and the later is the sole species that interacts with the proteasome. Inhibits the proteasome in intact cells (IC50 approximately 1 µM). clasto-Lactacystin β-lactone shows 5-10 fold greater potency than lactacystin in vitro.
      FormWhite solid
      CAS number154226-60-5
      Chemical formulaC₁₀H₁₅NO₄
      Structure formulaStructure formula
      SolubilityDMSO (3 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Rapidly hydrolyzed in aqueous buffers.
      Toxicity Standard Handling
      ReferencesCorey, E.J., and Wei-Dong, Z. 1999. Chem. Pharm. Bull. 47, 1.
      Dick, L.R., et al. 1997. J. Biol. Chem. 272, 182.
      Dick, L.R., et al. 1996. J. Biol. Chem. 271, 7273.
      Fenteany, G., et al. 1995. Science 268, 726.
      Citation
    • Liguo Zhang, Kenneth P. Nephew and Patricia J. Gallagher. (2007) Regulation of death-associated protein kinase: stabilization by HSP90 heterocomplexes. Journal of Biological Chemistry 282, 11795-11804.
      		•