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654380 Sigma-AldrichTunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 654380) on sigmaaldrich.com.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet
Citations

Recommended Products

Overview

Replacement Information

Key Spec Table

CAS #	Empirical Formula
11089-65-9	C₃₉H₆₄N₄O₁₆

Pricing & Availability

Catalogue Number	Availability	Packaging	Qty/Pack	Price	Quantity
654380-10MG	Retrieving availability... — Fulfillment and delivery delayed In Stock Discontinued Limited Quantities Available Availability to be confirmed Login to See Inventory In Stock Fulfillment and delivery delayed In Stock Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Glass bottle	10 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites
654380-50MG	Retrieving availability... — Fulfillment and delivery delayed In Stock Discontinued Limited Quantities Available Availability to be confirmed Login to See Inventory In Stock Fulfillment and delivery delayed In Stock Remaining : Will advise Remaining : Will advise Will advise Contact Customer Service Contact Customer Service Contact Customer Service Contact Customer Service	Alu drum	50 mg	Retrieving price... Price could not be retrieved Minimum Quantity is a multiple of Maximum Quantity is Upon Order Completion More Information You Saved () — Request Pricing Login to See Your Pricing	Check Availability —	Add To Favorites Add To Favorites Added To My Favorites

Description
Overview	A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells. Also available as a 25 mM solution in DMSO (Cat. No. 504570).
Catalogue Number	654380
Brand Family	Calbiochem®

References
References	Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857. Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.

Product Information
CAS number	11089-65-9
Form	White to off-white solid
Hill Formula	C₃₉H₆₄N₄O₁₆
Chemical formula	C₃₉H₆₄N₄O₁₆
Reconstitution	Aqueous solutions can be prepared from stock solutions in DMSO by diluting with H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0 (preferably >8.0).
Structure formula Image
Quality Level	MQ200

Applications

Biological Information
Primary Target	N-linked glycosylation
Secondary target	thrombin-induced Ca²⁺ mobilization in cells
Purity	≥98% by HPLC (A+B+C+D)

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	YO7980200

Safety Information
R Phrase	R: 26/27/28-60-61 Very toxic by inhalation, in contact with skin and if swallowed. May impair fertility. May cause harm to the unborn child.
S Phrase	S: 22-36/37/39-45 Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Hazardous Materials Attention:	Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage	+15°C to +30°C
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
654380-10MG	04055977184686
654380-50MG	04055977184693

Documentation

Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

Tunicamycin, Streptomyces lysosuperficus - CAS 11089-65-9 - Calbiochem Certificates of Analysis

Title	Lot Number
654380	Enter Lot Number

References

Reference overview
Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857. Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.

Citations

Title

Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490.

Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423.

Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-September-2007 RFH
Description	A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca²⁺ mobilization in cells.
Form	White to off-white solid
CAS number	11089-65-9
RTECS	YO7980200
Chemical formula	C₃₉H₆₄N₄O₁₆
Structure formula
Purity	≥98% by HPLC (A+B+C+D)
Solubility	DMSO (10 mg/ml), DMF, or Pyridine. Aqueous solutions can be prepared from DMSO stock solutions by diluting in H₂O at pH 8.0 to 10.0 or with appropriate buffers at pH >7.0.
Storage	+15°C to +30°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity	Highly Toxic & Carcinogenic / Teratogenic
Merck USA index	14, 9819
References	Tordai, A., et al. 1995. Biochem. Biophys. Res. Commun. 206, 857. Price, B.D., et al. 1992. J. Cell Physiol. 152, 545.
Citation	Ray S. Oh, Xinli Bai and Johanna M. Rommens. (2006) Human homologs of UbC6P ubiquitin-conjugating enzyme and phosphorylation of HSUbC6E in response to endoplasmic reticulum stress. Journal of Biological Chemistry 281, 21480-21490. Wolfdieter Springer, et al. (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress. Human Molecular Genetics 14, 3407-3423. Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.

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