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567021 Simvastatin, Sodium Salt - Calbiochem

Simvastatin, Sodium Salt is a carboxylate form of Simvastatin. Active in whole cells and in cell-free preparations. An inhibitor of HMG-CoA reductase.

Simvastatin, Sodium Salt - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-Type Calcium Channel Blocker VI

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
567021
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₅H₃₉O₆ • Na

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
567021-50MG
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      		 Glass bottle 50 mg
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      567021-5MG
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      Fulfillment and delivery delayed Fulfillment and delivery delayed
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      Limited Quantities Available
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          		 Plastic ampoule 5 mg
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          Description
          OverviewCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free preparations. Also available as a 10 mM solution in H2O (Cat. No. 567022).
          Catalogue Number567021
          Brand Family Calbiochem®
          SynonymsL-Type Calcium Channel Blocker VI
          References
          ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Product Information
          ATP CompetitiveN
          FormBeige solid
          Hill FormulaC₂₅H₃₉O₆ • Na
          Chemical formulaC₂₅H₃₉O₆ • Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          567021-50MG 04055977267112
          567021-5MG 07790788051587

          Documentation

          Simvastatin, Sodium Salt - Calbiochem Certificates of Analysis

          TitleLot Number
          567021

          References

          Reference overview
          Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-October-2015 JSW
          SynonymsL-Type Calcium Channel Blocker VI
          DescriptionCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₅H₃₉O₆ • Na
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml), Ethanol (25 mg/ml), or H₂O (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.