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553509 Ras/Rac Transformation Blocker, SCH 51344 - CAS 171927-40-5 - Calbiochem

Ras/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline

Primary Target: Ras/Rac
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553509
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Overview

Key Spec Table

CAS #Empirical Formula
171927-40-5C₁₆H₂₀N₄O₃

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553509-10MG
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      Description
      OverviewA cell-permeable pyrazoloquinoline compound that acts as an effective blocker of Ras-induced malignant transformation and inhibits Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex and membrane ruffling. The effect of SCH 51344 is limited to Ras/Rac pathway(s) other than those involving ERK and JNK. Shown to directly target human mutT homolog MTH1/NUDT1 with a Kd of 49 nM and inhibit its catalytic activity (IC50 for pyrophosphate release during nucleotide triphosphate hydrolysis = 215, 410 and 675 nM against dGTP, 8-oxo-dGTP and 2-OH-dATP substrates, respectively).
      Catalogue Number553509
      Brand Family Calbiochem®
      Synonyms6-Methoxy-4-(2-((2-hydroxyethoxyl)-ethyl)amino)-3-methyl-1H-pyrazolo[3,4-b]quinoline
      References
      ReferencesHuber, K. V. M., et al. 2014. Nature In press.
      He, H., et al. 1998. Mol. Cell. Biol. 18, 3829.
      Walsh, A.B., et al. 1997. Oncogene 15, 2553.
      Chandra Kumar, C., et al. 1995. Cancer Res. 55, 5106.
      Product Information
      CAS number171927-40-5
      ATP CompetitiveN
      FormLight-yellow solid
      Hill FormulaC₁₆H₂₀N₄O₃
      Chemical formulaC₁₆H₂₀N₄O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationRas/Rac Transformation Blocker, SCH 51344, CAS 171927-40-5, is a blocker of Ras-induced malignant transformation & Ras/Rac-dependent dissociation of EMS1 from the actin-myosin II complex.
      Biological Information
      Primary TargetRas/Rac
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      553509-10MG 04055977193688