Millipore Sigma Vibrant Logo

559286 RSK Inhibitor II - CAS 501437-28-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
501437-28-1C₁₉H₂₃F₂N₅O₂

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
559286-5MG
Fulfillment and delivery delayed
Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Glass bottle 5 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewThe racemic mixture of a cell-permeable dihydropteridinone that acts as a potent and selective RSK inhibitor (IC50 ≤31 nM against RSK1, 2, 3, and 4; [ATP] = 100 µM) by targeting RSK N-terminal kinase domain in an ATP-competitive manner, while inhibiting 11 other kinases only at higher concentrations (IC50 ≥100 nM) and displaying little activity against 39 others. Shown to selectively inhibit RSK-dependent, but not RSK-independent, cellular protein phosphorylations in PMA-stimulated HEK-293 cells and EGF-stimulated Rat-2 cells (IC50 ~1 µM).
      Catalogue Number559286
      Brand Family Calbiochem®
      Synonyms2-(3,5-Difluoro-4-hydroxy-anilino)-8-isopentyl-5,7-dimethyl-7H-pteridin-6-one, racemic, p90 Ribosomal S6 Kinase Inhibitor II, BI-D1870, BID-1870, BID1870
      References
      ReferencesCarriere, A., et al. 2008. Curr. Biol. 18, 1269
      Sapkota, G.P., et al. 2007. Biochem. J. 401, 29.
      Zaru, R., et al. 2007. Nat. Immunol. 8, 1227.
      Product Information
      CAS number501437-28-1
      FormOff-white solid
      Hill FormulaC₁₉H₂₃F₂N₅O₂
      Chemical formulaC₁₉H₂₃F₂N₅O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      559286-5MG 04055977192377