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508509 NS309 - CAS 18711-16-5 - Calbiochem

A potent activator of Ca2+ -activated K+ channels of SK and IK types, but not BK type channels. It is at least 1000 times more potent than 1-EBIO.

NS309 - CAS 18711-16-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ca2+ -activated K+ Channels Activator, NS309, NS-309, NS 309

Primary Target: Ca2+-activated K+ channels
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
18711-16-5C₈H₄Cl₂N₂O₂

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      Description
      OverviewA potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number508509
      Brand Family Calbiochem®
      SynonymsCa2+ -activated K+ Channels Activator, NS309, NS-309, NS 309
      References
      ReferencesLeurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol. 377, 101.
      Morimura, K. et al. 2006. J. Pharmacol. Sci. 100, 237.
      Strobaek, D. et al. 2004. Biochim. Biophys. Acta. 1665, 1.
      Product Information
      CAS number18711-16-5
      FormYellow solid
      Hill FormulaC₈H₄Cl₂N₂O₂
      Chemical formulaC₈H₄Cl₂N₂O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCa2+-activated K+ channels
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      5085090001 04055977262025

      Documentation

      NS309 - CAS 18711-16-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      Leurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol. 377, 101.
      Morimura, K. et al. 2006. J. Pharmacol. Sci. 100, 237.
      Strobaek, D. et al. 2004. Biochim. Biophys. Acta. 1665, 1.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-January-2014 JSW
      SynonymsCa2+ -activated K+ Channels Activator, NS309, NS-309, NS 309
      DescriptionA potent activator of Ca2+ -activated K+ channels of SK and IK types but not BK type channels. NS309 is at least 1000 times more potent than 1-EBIO and at least 30 times more potent than DC-EBIO when the compounds are compared on the same cell. NS309 blocks L-type Calcium channels with IC50 = 10 µM/L. Recently, this compound has been shown to produce endothelium-dependent hyperpolarizations in guinea pig carodid arteries by opening KCa2.3 and KCa3.1 channels demonstrating a new therapeutic option for treating hypertension.
      FormYellow solid
      CAS number18711-16-5
      Chemical formulaC₈H₄Cl₂N₂O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (100 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLeurangue, V. et al. 2008. Naunyn Schmiedebergs Arch. Pharmacol. 377, 101.
      Morimura, K. et al. 2006. J. Pharmacol. Sci. 100, 237.
      Strobaek, D. et al. 2004. Biochim. Biophys. Acta. 1665, 1.