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475981 Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem

The Myosin Light Chain Kinase Inhibitor Peptide 18 controls the biological activity of Myosin Light Chain Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: MLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV

Primary Target: Mlck
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475981
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₆₀H₁₀₅N₂₃O₁₁

Pricing & Availability

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475981-5MG
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      		 Plastic ampoule 5 mg
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      Description
      OverviewA highly basic, cell-permeable, nonapeptide that acts as a selective Myosin Light Chain Kinase (MLCK) inhibitor (IC50 = 50 nM). The inhibition is competitive with respect to the peptide substrate (Ki = 52 nM) and displays a mixed mode of inhibition with respect to ATP. Does not interfere with kinase activation by calmodulin (CaM), nor does it inhibit the activities of CaMKII and PKA.
      Catalogue Number475981
      Brand Family Calbiochem®
      SynonymsMLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV
      References
      ReferencesZolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
      Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₆₀H₁₀₅N₂₃O₁₁
      Chemical formulaC₆₀H₁₀₅N₂₃O₁₁
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMlck
      Primary Target IC<sub>50</sub>50 nM against MLCK
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475981-5MG 04055977184365

      Documentation

      Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Myosin Light Chain Kinase Inhibitor Peptide 18 - Calbiochem Certificates of Analysis

      TitleLot Number
      475981

      References

      Reference overview
      Zolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
      Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-December-2008 JSW
      SynonymsMLCK Inhibitor Peptide 18, H-RKKYKYRRK-NH₂, MLCK Inhibitor IV
      DescriptionA highly basic, cell-permable, nonapeptide that acts as a selective myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM). Does not block calmodulin (CaM) or inhibit the kinase activities of Ca2+/calmodulin kinase II (CaMKII) or protein kinase A (PKA). Inhibition is competitive with respect to substrate (Ki = 52 nM). Displays mixed mode inhibition with respect to ATP.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₆₀H₁₀₅N₂₃O₁₁
      Peptide SequenceH-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH₂
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesZolotarevsky, Y., et al. 2002. Gastroenterology 123, 163.
      Lukas, T.J., et al. 1999. J. Med. Chem. 42, 910.