480073 Sigma-AldrichMLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem
MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function.
More>> MLKL Inhibitor, Necrosulfonamide, CAS 432531-71-0, is a cell-permeable inhibitor that covalently modifies Cys88 and blocks human MLKL adaptor function. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-Like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide, Necrosis Inhibitor III
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Overview
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Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 480073-25MG |
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Glass bottle | 25 mg |
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| Description | |
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| Overview | A cell-permeable acrylamide compound that inhibits human, but not murine, MLKL adaptor function via covalent modification of Cys86 and is more potent than Nec-1 (Cat. No. 480065) in preventing necrotic/necroptotic death in human HT-29 (IC50 = 124 nM and 2 µM, respectively), being ineffective against necrosis/necroptosis in murine L929 or apoptosis in human RIP3-null Panc-1 cells. Unlike Nec-1, which prevents necrosome formation by blocking RIP1-RIP3 interaction, MLKL prevents the MLKL-RIP1-RIP3 necrosome complex from interacting with further downstream effectors. |
| Catalogue Number | 480073 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-N-(4-(N-(3-Methoxypyrazin-2-yl)sulfamoyl)phenyl)-3-(5-nitrothiophene-2-yl)acrylamide, Mixed Lineage Kinase Domain-Like Protein Inhibitor, Necrosome Inhibitor II, Necrosulfonamide, Necrosis Inhibitor III |
| References | |
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| References | Dunai, Z.A., et al. 2012. PLoS One 7, e41945. Sun, L., et al. 2012. Cell 148, 213. |
| Product Information | |
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| CAS number | 432531-71-0 |
| Form | Dark yellow solid |
| Hill Formula | C₁₈H₁₅N₅O₆S₂ |
| Chemical formula | C₁₈H₁₅N₅O₆S₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | human MLKL |
| Purity | ≥95% by HPLC |
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| Cell permeable | Y |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 480073-25MG | 04055977201895 |
Documentation
MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 480073 |
References
| Reference overview |
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| Dunai, Z.A., et al. 2012. PLoS One 7, e41945. Sun, L., et al. 2012. Cell 148, 213. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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