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14-779M MKP5, active

MKP5, active MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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14-779M
250 µg  Also available in 10μg size as catalog # 14-779 and in 250 μg as catalog # 14-779M.
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      Overview

      Replacement Information
      Description
      Catalogue Number14-779M
      Trade Name
      • Upstate
      DescriptionMKP5, active
      OverviewDual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the
      phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAPK superfamily
      (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members ofthis family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue
      distribution and subcellular localization, and different modes of inducibility of their expression by extracellular
      stimuli. This gene product binds to and inactivates p38 and SAPK/JNK, but not MAPK/ERK. Its subcellular localization
      is unique; it is evenly distributed in both the cytoplasm and the nucleus. This gene is widely expressed in various
      tissues and organs, and its expression is elevated by stress stimuli. Three transcript variants encoding two different
      isoforms have been found for this gene.
      References
      Product Information
      PresentationProtein in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
      Quality LevelMQ100
      Applications
      Key Applications
      • Phosphatase Assay
      Biological Information
      SourceN-terminal 6His-tagged, recombinant, human MKP5, amino acids 320-end, expressed in E. coli.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • DUSP10
      • MKP5
      Purification MethodPurified using Ni2+/NTA agarose.
      UniProt Number
      Molecular Weight20.6 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by the release of phosphate from the substrate 6,8-difluoro-4-methylumbelliferyl phosphate (DiFMUP)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10μg size as catalog # 14-779 and in 250 μg as catalog # 14-779M.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-779M 04053252278846

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-779 MKP5, active Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Phosphatases
      Life Science Research > Proteins and Enzymes > Purified Phosphatases