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SCC276 MCF-7 BUS Human Invasive Ductal Carcinoma Cell Line

MCF-7 BUS is a well-characterized cellular model for estrogen-responsive metastatic breast cancer.

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SCC276
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC276
      DescriptionMCF-7 BUS Human Invasive Ductal Carcinoma Cell Line
      Alternate Names
      • MCF-7/BUS
      • MCF7/BUS
      • MCF7 BUS
      Background InformationHormonal response is an important characteristic of mammary cell growth and differentiation (1). Malignant mammary epithelial cells expressing estrogen receptor (ER) may exhibit enhanced proliferation in response to estrogen hormones, underscoring the necessity of research on cellular models recapitulating this trait and helping to inform the most effective avenues of therapeutic development for ER-positive breast cancers. MCF7 was one of the first established breast cancer cell lines, retaining characteristics of differentiated mammary epithelium, such as processing of estradiol via cytoplasmic estrogen receptors (2). MCF7-BUS is a subline of MCF7 that demonstrates the highest proliferative response to estradiol-17ß (E2) among MCF7 sublines (3,4). MCF7-BUS is a slow-growing line with tendency to form clusters in culture. MCF7-BUS cells have been validated for dose-response to estradiol. MCF7-BUS represents a clinically applicable and well-characterized cellular model for estrogen-responsive metastatic breast cancer.

      Source
      MCF7-BUS is a subclone of the MCF7 cell line isolated from pleural effusion from a 69-year -old female patient with metastatic breast cancer (2).

      References
      1. Endocrinology 2002, 143(9): 3427-3434.
      2. J Natl Cancer Inst 1973, 51(5): 1409-1416.
      3. Best Pract Res Clin Endocrinol Metab 2006, 20(1): 15-33.
      4. Environ Heath Perspect 1995, 103(9): 844-850.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationMCF-7 BUS is a well-characterized cellular model for estrogen-responsive metastatic breast cancer.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEach vial contains ≥1X10⁶ viable cells.

      Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.

      Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, Chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services

      Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsCells should be stored in liquid nitrogen until use. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC276 04065267034607