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434610 Leukadherin-1 - CAS 344897-95-6 - Calbiochem

A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fib

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Leukadherin-1 - CAS 344897-95-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, αMβ2 Agonist II, CD11b Agonist II

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434610
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Overview

Key Spec Table

CAS #Empirical Formula
344897-95-6C₂₂H₁₅NO₄S₂

Pricing & Availability

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434610-25MG
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      Description
      OverviewA furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo.
      Catalogue Number434610
      Brand Family Calbiochem®
      SynonymsLA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, αMβ2 Agonist II, CD11b Agonist II
      References
      ReferencesMaiguel, D., et al. 2011. Sci. Signal. 4, ra57.
      Product Information
      CAS number344897-95-6
      FormRed-brown solid
      Hill FormulaC₂₂H₁₅NO₄S₂
      Chemical formulaC₂₂H₁₅NO₄S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥95% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      434610-25MG 04055977210217