434610 Sigma-AldrichLeukadherin-1 - CAS 344897-95-6 - Calbiochem
A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fib
More>> A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Less<<Leukadherin-1 - CAS 344897-95-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, αMβ2 Agonist II, CD11b Agonist II
Recommended Products
Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 344897-95-6 | C₂₂H₁₅NO₄S₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 434610-25MG |
|
Glass bottle | 25 mg |
|
— |
| Description | |
|---|---|
| Overview | A furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo. |
| Catalogue Number | 434610 |
| Brand Family | Calbiochem® |
| Synonyms | 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, LA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, αMβ2 Agonist II, CD11b Agonist II |
| References | |
|---|---|
| References | Maiguel, D., et al. 2011. Sci. Signal. 4, ra57. |
| Product Information | |
|---|---|
| CAS number | 344897-95-6 |
| Form | Red-brown solid |
| Hill Formula | C₂₂H₁₅NO₄S₂ |
| Chemical formula | C₂₂H₁₅NO₄S₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 434610-25MG | 04055977210217 |