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SCC201 LOX-IMVI Human Melanoma Cell Line

LOX-IMVI human melanoma cell line is an excellent model for probing mechanisms of metastasis and for evaluation of chemotherapies.

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SCC201
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC201
      DescriptionLOX-IMVI Human Melanoma Cell Line
      OverviewThe LOX-IMVI human melanoma cell line is widely used as an in vitro model system to study tumor metastasis and to test for chemosensitivity to potential anti-cancer compounds. LOX-IMVI cells exhibit a tendency to form lung metastases in nude mice independent of the inoculation site (2), and mortality of experimental animals is observed within 3-5 weeks of LOX-IMVI cell injection (3). LOX-IMVI cells are genetically characterized by lack of the Y chromosome and trisomy 7 (2), and are heterozygous for the BRAF V600E melanoma driver mutation (4). LOX-IMVI cells are amelanotic and express the human melanoma marker GD3 ganglioside, a factor in metastatic potential of malignant melanoma (5).

      Source:
      The LOX-IMVI human melanoma cell line was established from a subcutaneous xenograft in nude mice from a lymph node metastasis of a 58-year-old Caucasian male patient with malignant amelanotic melanoma (2).
      Alternate Names
      • LOX/IMVI
      • LOX IMVI
      • LOXIM-VI
      • LOXIMVI
      Background InformationMalignant melanoma is highly treatable when diagnosed early, but can spread rapidly if undetected, resulting in the highest mortality among skin cancer types. Lymph nodes and lungs are the most common sites of melanoma metastases (1), and because of the poor prognosis and limited efficacy of current treatments, metastatic melanoma has generated intense interest as a target for therapeutic intervention.

      References:
      1. Tas F (2012). J Oncol 2012: 647684
      2. Fodstad O, Aamdal S, McMenamin M, Nesland JM, Pihl A (1988) Int J Cancer 41(3): 442-449.
      3. KjØnniksen I, Storeng R, Pihl A, McLemore TL, Fodstad O (1989) Cancer Res 49(18): 5148-5152.
      4. Ikediobi ON et al., (2006) Mol Cancer Ther 5(11): 2606-2612.
      5. Hamamura K et al., (2005) PNAS 102(31): 11041-11046.
      References
      Product Information
      Applications
      ApplicationLOX-IMVI human melanoma cell line is an excellent model for probing mechanisms of metastasis and for evaluation of chemotherapies.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for HPV-16, HPV-18, Hepatitis A, B, C, and HIV-1 & 2 viruses by PCR.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC201 04054839736131