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14-686M LOK Protein, active, 250 µg

Active, N-terminal 6His-tagged, recombinant human LOK amino acids 1-348, for use in Kinase Assays.

14-686M
250 µg  Also available in 10 μg size (cat#14-686) and in bulk (cat#14-686-K).
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      Overview

      Replacement Information
      Description
      Catalogue Number14-686M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionLOK Protein, active, 250 µg
      OverviewN-terminal 6His-tagged, recombinant human LOK amino acids 1-348
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal 6His-tagged, recombinant human LOK amino acids 1-348, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.
      Gene Symbol
      • STK10
      • PRO2729
      • LOK
      Protein TargetLOK
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O94804 # Can act on substrates such as myelin basic protein and histone 2A on serine and threonine residues (By similarity).
      SIZE: 968 amino acids; 112135 Da
      TISSUE SPECIFICITY: Expressed predominantly in lymphoid organs.
      PTM: Autophosphorylated (By similarity).
      SIMILARITY: SwissProt: O94804 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain.
      Molecular Weight43.2kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of Axltide (Catalog# 12-516)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-686) and in bulk (cat#14-686-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      14-686M 04053252925177

      Documentation

      Related Products & Applications

      Alternative Packsize

      Catalogue Number Description  
      14-686 LOK Protein, active, 10 µg Show Pricing & Availability

      Product Families

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Categories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases