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551476 InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem

InSolution™ Q-VD-OPh, Non-O-methylated, is a cell-permeable, irreversible, broad-spectrum inhibitor of caspases (IC₅₀ = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

Primary Target: caspase-1
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551476
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₆H₂₅F₂N₃O₆

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
551476-1MG
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      		 Plastic ampoule 1 mg
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      551476-5MG
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          		 Glass bottle 5 mg
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          Description
          OverviewA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
          Catalogue Number551476
          Brand Family Calbiochem®
          SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
          References
          ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
          Caserta, T.M., et al. 2003. Apoptosis 8, 345.
          Rebbaa, A., et al. 2003. Oncogene 22, 2805.
          Product Information
          ATP CompetitiveN
          FormLiquid
          FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
          Hill FormulaC₂₆H₂₅F₂N₃O₆
          Chemical formulaC₂₆H₂₅F₂N₃O₆
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetcaspase-1
          Primary Target IC<sub>50</sub>50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceQ-Val-Asp-CH₂-OPh
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          551476-1MG 04055977268898
          551476-5MG 04055977268904

          Documentation

          InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem SDS

          Title

          Safety Data Sheet (SDS) 

          InSolution™ Q-VD-OPh, Non-O-methylated - Calbiochem Certificates of Analysis

          TitleLot Number
          551476

          References

          Reference overview
          Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
          Caserta, T.M., et al. 2003. Apoptosis 8, 345.
          Rebbaa, A., et al. 2003. Oncogene 22, 2805.

          Brochure

          Title
          Caspases and other Apoptosis Related Tools Brochure

          Citations

          Title
        • Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
        • Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.
        • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-February-2012 RFH
          SynonymsN-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
          DescriptionA cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50 nM for caspase-1; IC50 = 100 nM for caspase-8; IC50 = 430 nM for caspase-9; IC50 < 25 nM for caspase-3). Exhibits effective anti-apoptotic properties against all major caspase-mediated cellular apoptosis pathways, including caspase 9/3, caspase 8/10, and caspase 12. Does not exhibit toxic effects even at high concentrations. To reduce hydrophobicity of the peptide and facilitate its use in aqueous media the aspartyl residue is not O-methylated. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
          FormLiquid
          FormulationSupplied as a 10 mM (1 mg/195 µl) solution in DMSO.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₆H₂₅F₂N₃O₆
          Peptide SequenceQ-Val-Asp-CH₂-OPh
          Structure formulaStructure formula
          Purity≥90% by HPLC
          Storage Protect from light
          -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
          Toxicity Irritant
          ReferencesBraun, J.S., et al. 2007. Exp. Neurol. 206, 183.
          Caserta, T.M., et al. 2003. Apoptosis 8, 345.
          Rebbaa, A., et al. 2003. Oncogene 22, 2805.
          Citation
        • Braun, J.S., et al. 2007. Exp. Neurol. 206, 183.
        • Jessica H. Dworet and Judy L. Meinkoth. 2006.Molecular Endocrinology 20, 1112.
        • Ademi E. Santiago-Walker, et al. (2005) Protein Kinase C δ Stimulates Apoptosis by Initiating G1 Phase Cell Cycle Progression and S Phase Arrest. Journal of Biological Chemistry 280, 32107-32114.
          		•